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JNJ-1661010 - ≥98%, high purity , CAS No.681136-29-8, Inhibitor of Fatty acid amide hydrolase;Inhibitor of Fatty acid amide hydrolase-2

Moligand™
≥98%

CAS#: 681136-29-8
Formula: C₁₉H₁₉N₅OS
Molecular Weight: 365.45
PubChem CID: 2809273

Item Number

J129865

Grouped product items
SKU	Size	Availability	Price	Qty
J129865-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$83.90
J129865-50mg	50mg	In stock	$276.90

Selective, reversible FAAH inhibitor

View related series

Fatty acid amide hydrolase Inhibitor Fatty acid amide hydrolase-2 Inhibitor

Basic Description

Synonyms	681136-29-8\|JNJ-1661010\|JNJ 1661010\|1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-\|N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide\|JNJ1661010\|Takeda-25\|N-PHENYL-4-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)-1-PIPERAZINECARB
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50= 12 nM). Brain penetrant and activein vivo.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Fatty acid amide hydrolase;Inhibitor of Fatty acid amide hydrolase-2
Note	卖完停产，不再备货
Product Description	JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. A selective and reversible inhibitor of fatty acid amide hydrolase (FAAH).

Associated Targets

PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities

Discover Target: PTH1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FAAH2 Tchem Fatty-acid amide hydrolase 2 1 Activities

Discover Target: FAAH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 8 Activities

Discover Target: FAAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

Discover Target: SMAD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATXN2 Tbio Ataxin-2 0 Activities

Discover Target: ATXN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UBE2N Tchem Ubiquitin-conjugating enzyme E2 N 0 Activities

Discover Target: UBE2N

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GNAS Tbio Protein ALEX 0 Activities

Discover Target: GNAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TARDBP Tchem TAR DNA-binding protein 43 0 Activities

Discover Target: TARDBP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Discover Target: ATAD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
INCHI	InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChi Key	BHBOSTKQCZEAJM-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
Isomeric SMILES	C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
PubChem CID	2809273
Molecular Weight	365.45

CAS Registry No.

681136-29-8

PubChem CID

2809273

ChEMBL Ligand

CHEMBL460273

Certificates

Certificate of Analysis(COA)

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Lot Number	Certificate Type	Date	Item
J1514083	Certificate of Analysis	May 10, 2023	J129865

Solubility

Solvent:DMSO, Max Conc. mg/mL: 36.55, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.65, Max Conc. mM: 10

Melt Point(°C)

240.48°C

References

1. Karbarz MJ, Luo L, Chang L, Tham CS, Palmer JA, Wilson SJ, Wennerholm ML, Brown SM, Scott BP, Apodaca RL et al.. (2009) Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.. Anesth Analg, 108 (1): (316-29). [PMID:19095868]

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