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JNJ 17203212 - ≥99%(HPLC), high purity , CAS No.821768-06-3, Channel blocker of TRPV1
Reversible, competitive and potent TRPV1 antagonist
Basic Description Synonyms JNJ-17203212|821768-06-3|JNJ 17203212|1-Piperazinecarboxamide, 4-(3-(trifluoromethyl)-2-pyridinyl)-N-(5-(trifluoromethyl)-2-pyridinyl)-|JNJ17203212|4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide|CHEMBL25477 Specifications & Purity Moligand™, ≥99%(HPLC) Biochemical and Physiological Mechanisms Reversible, competitive and potent TRPV1 antagonist (pKivalues are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50values are 6.32 and 7.23 respectively) and exhibits antitussi Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type CHANNEL BLOCKER Mechanism of action Channel blocker of TRPV1
Names and Identifiers Pubchem Sid 488197410 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488197410 IUPAC Name 4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide INCHI InChI=1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29) InChi Key JFRYYGVYCWYIDQ-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1C2=C(C=CC=N2)C(F)(F)F)C(=O)NC3=NC=C(C=C3)C(F)(F)F Isomeric SMILES C1CN(CCN1C2=C(C=CC=N2)C(F)(F)F)C(=O)NC3=NC=C(C=C3)C(F)(F)F PubChem CID 11339118 Molecular Weight 419.32
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 41.93, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 41.93, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H301: Toxic if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P337+P317: If eye irritation persists: Get medical help.
References 1. Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C et al. . (2005) Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.. J Med Chem, 48 (6): (1857-72). [PMID:15771431 ]
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C2304599