| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| J654907-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $682.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pK i values of 9.1 and 7.9 for rat and human P2X7 channels, respectively. In Vivo When dosed in rats, JNJ-42253432 occupied the brain P2X7 channel with an ED 50 of 0.3 mg/kg, corresponding to a mean plasma concentration of 42 ng/ml. JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED 50 of 10 mg/kg for SERT occupancy . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Canonical SMILES | O=C(NCC1(CCCCC1)N2CCN(CC2)C3=CC=CC=C3)C4=CC=CC5=C4CCN(C5)C |
|---|---|
| Molecular Weight | 446.63 |
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