JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Click Here for 5% Off Your First Aladdin Purchase!

྾

Home
Applications
Targets
Kinases
TK:Tyrosine kinase
JNJ-64264681 , CAS No.J611273, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of tec protein tyrosine kinase

Skip to the end of the images gallery

Skip to the beginning of the images gallery

JNJ-64264681 , CAS No.J611273, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of tec protein tyrosine kinase

Moligand™

PubChem CID: 129234005

Item Number

J611273

Grouped product items
SKU	Size	Availability	Price	Qty
J611273-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
J611273-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,790.90

View related series

BLK proto-oncogene，Src family tyrosine kinase Inhibitor BMX non-receptor tyrosine kinase Inhibitor Bruton tyrosine kinase Inhibitor tec protein tyrosine kinase Inhibitor

Basic Description

Synonyms	compound 13;JNJ64264681
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of tec protein tyrosine kinase

Associated Targets

TEC Tchem Tyrosine-protein kinase Tec 0 Activities

Discover Target: TEC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMX Tchem Cytoplasmic tyrosine-protein kinase BMX 0 Activities

Discover Target: BMX

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BLK Tchem Tyrosine-protein kinase Blk 0 Activities

Discover Target: BLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C27H30N6O3S/c1-5-21(34)30-17-7-6-8-18(17)31-25(35)24-23-22-19(9-10-28-26(22)37-24)33(27(36)32-23)20-13-29-16(11-14(2)3)12-15(20)4/h5,9-10,12-14,17-18H,1,6-8,11H2,2-4H3,(H,30,34)(H,31,35)(H,32,36)/t17-,18+/m0/s1
InChi Key	OPLNLPWGEZNZFL-ZWKOTPCHSA-N
Canonical SMILES	C=CC(=O)N[C@H]1CCC[C@H]1NC(=O)c1sc2nccc3c2c1[nH]c(=O)n3c1cnc(cc1C)CC(C)C
PubChem CID	129234005

Database links

PubChem CID	129234005

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Tichenor MS, Wiener JJM, Rao NL, Bacani GM, Wei J, Pooley Deckhut C, Barbay JK, Kreutter KD, Chang L, Clancy KW et al.. (2022) Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.. J Med Chem, 129 (3): (589-97). [PMID:36314537]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.