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JP 1302 dihydrochloride - ≥99%, high purity , CAS No.80259-18-3, Antagonist of α 2C-adrenoceptor

Moligand™
≥99%

CAS#: 80259-18-3
Formula: C₂₄H₂₄N₄・2HCl
Molecular Weight: 441.4
PubChem CID: 540335

Item Number

J335104

Grouped product items
SKU	Size	Availability	Price	Qty
J335104-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$175.90
J335104-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$733.90

a selective α2C-AR

View related series

α2C-adrenoceptor Antagonist

Basic Description

Synonyms	80259-18-3\|N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine\|JP1302\|N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine\|GNF-PF-3427\|TCMDC-123912\|JP 1302\|JP-1302\|MMV006172\|N-(4-(4-methylpiperazin-1-yl)phenyl)acridin-9-amine\|CHEMBL106525\|9-Acridinamine, N
Specifications & Purity	Moligand™, ≥99%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of α 2C-adrenoceptor
Product Description	JP 1302 dihydrochloride is a potent and selective α2C-AR adrenoreceptor antagonist. JP 1302 dihydrochloride strongly antagonizes adrenaline-stimulated 35GTPγS binding\|in vitro\|.

Associated Targets

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

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FEN1 Tchem Flap endonuclease 1 0 Activities

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WRN Tbio Werner syndrome ATP-dependent helicase 0 Activities

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POLK Tbio DNA polymerase kappa 0 Activities

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POLI Tchem DNA polymerase iota 0 Activities

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RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

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BLM Tchem Bloom syndrome protein 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 3 Activities

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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GLA Tclin Alpha-galactosidase A 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Names and Identifiers

IUPAC Name	N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine
INCHI	InChI=1S/C24H24N4/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24/h2-13H,14-17H2,1H3,(H,25,26)
InChi Key	QZKGUNQLVFEEBA-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53
Isomeric SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53
RTECS	AR7147000
PubChem CID	540335
Molecular Weight	441.4

CAS Registry No.

PubChem CID

ChEMBL Ligand

GPCRdb Ligand

Solubility

Soluble in DMSO (5 mM), and water (100 mM).

Refractive Index

n20D1.71

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