| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| J656452-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $528.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In | Dry ice |
| Product Description | JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity. In Vivo JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly . JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis. JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female mice of a transgenic mouseDosage: 50 mg/kg Administration: i.p.; daily from 63 to 98 days Result: Caused a significant delay in the increase of tumour burden during the first 2 weeks of treatment. However, on days 84, 91 and 98 no significant differences between both groups could be detected. |
| Canonical SMILES | O=C([C@H]1O[C@@H]1C(N[C@H](C(NCCC2=CC=C(O)C=C2)=O)CC(C)C)=O)OCC |
|---|---|
| Molecular Weight | 392.45 |
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