JTV-803 , CAS No.247131-06-2, Inhibitor of coagulation factor X

Item Number

J611285

Grouped product items
SKU	Size	Availability	Price	Qty
J611285-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
J611285-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	JTV-803 free base\|UNII-P7Z08VK9XO\|P7Z08VK9XO\|CHEMBL1182177\|247131-06-2\|4-Piperidinecarboxylic acid, 4-(((2-(aminoiminomethyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)oxy)methyl)-1-(4-pyridinyl)-\|CHEMBL216829\|JTV803\|SCHEMBL6191447\|GTPL11364\|MISBTXJXWSXZBF-UHFFF
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of coagulation factor X

Names and Identifiers

IUPAC Name	4-[(2-carbamimidoyl-3,4-dihydro-1H-isoquinolin-7-yl)oxymethyl]-1-pyridin-4-ylpiperidine-4-carboxylic acid
INCHI	InChI=1S/C22H27N5O3/c23-21(24)27-10-5-16-1-2-19(13-17(16)14-27)30-15-22(20(28)29)6-11-26(12-7-22)18-3-8-25-9-4-18/h1-4,8-9,13H,5-7,10-12,14-15H2,(H3,23,24)(H,28,29)
InChi Key	MISBTXJXWSXZBF-UHFFFAOYSA-N
Canonical SMILES	NC(=N)N1CCc2c(C1)cc(cc2)OCC1(CCN(CC1)c1ccncc1)C(=O)O
Isomeric SMILES	C1CN(CC2=C1C=CC(=C2)OCC3(CCN(CC3)C4=CC=NC=C4)C(=O)O)C(=N)N
PubChem CID	9844392

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

References

1. Hayashi M, Matsuo A, Nakamoto H, Aisaka K. (2001) Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals.. Eur J Pharmacol, 412 (1): (61-6). [PMID:11166737]
2. Hayashi M, Hamada A, Okaya Y, Wakitani K, Aisaka K. (2001) Inhibitory effect of JTV-803, a new cyclic guanidine derivative, on factor Xa in vitro and in vivo.. Eur J Pharmacol, 428 (2): (163-8). [PMID:11675032]
3. Asakura H, Ichino T, Yoshida T, Suga Y, Ontachi Y, Mizutani T, Kato M, Ito T, Yamazaki M, Aoshima K et al.. (2002) Beneficial effect of JTV-803, a new synthetic inhibitor of activated factor X, against both lipopolysaccharide-induced and tissue factor-induced disseminated intravascular coagulation in rat models.. Blood Coagul Fibrinolysis, 13 (3): (233-9). [PMID:11943937]

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Basic Description