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JZL184 - ≥97%, high purity , CAS No.1101854-58-3, Inhibitor of Monoacylglycerol lipase

Moligand™
≥97%

CAS#: 1101854-58-3
Formula: C₂₇H₂₄N₂O₉
Molecular Weight: 520.5
PubChem CID: 25021165

Item Number

J129444

Grouped product items
SKU	Size	Availability	Price
J129444-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$34.90
J129444-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$142.90
J129444-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$474.90
J129444-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,068.90

Potent MAGL inhibitor

View related series

Monoacylglycerol lipase Inhibitor

Basic Description

Synonyms	JZL184\|1101854-58-3\|JZL 184\|JZL-184\|4-nitrophenyl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate\|7MZ1I2J68A\|CHEMBL576786\|4-Nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate\|1-Piperidinecarboxylic ac
Specifications & Purity	≥97%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Monoacylglycerol lipase
Product Description	application： JZL 184 has been used as an inhibitor of monoacylglycerol lipase to study its effect on human osteoblast differentiation and proliferation and postsynaptic neurons.

Associated Targets

FAAH Tchem Fatty-acid amide hydrolase 1 1 Activities

Discover Target: FAAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGLL Tchem Monoglyceride lipase 16 Activities

Discover Target: MGLL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
INCHI	InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2
InChi Key	SEGYOKHGGFKMCX-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
Isomeric SMILES	C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
PubChem CID	25021165
Molecular Weight	520.5

CAS Registry No.

Wikipedia

PubChem CID

ChEMBL Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
I2205056	Certificate of Analysis	Jun 18, 2024	J129444
I2205057	Certificate of Analysis	Jun 18, 2024	J129444
I2205058	Certificate of Analysis	Jun 18, 2024	J129444
I2205101	Certificate of Analysis	Jun 18, 2024	J129444

Solubility

Solvent:DMSO, Max Conc. mg/mL: 52.05, Max Conc. mM: 100

Sensitivity

Moisture sensitive.

References

1. Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL et al.. (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.. Proc Natl Acad Sci USA, 106 (48): (20270-5). [PMID:19918051]
2. Long JZ, Nomura DK, Cravatt BF. (2009) Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism.. Chem Biol, 16 (7): (744-53). [PMID:19635411]
3. Navarro-Romero A et al.. (2022) Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome.. Elife, 11 [PMID:36217821]
4. Bluett RJ et al.. (2017) Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.. Nat Commun, 8 (14782). [PMID:28348378]

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