K252b - ≥97%(HPLC), high purity , CAS No.99570-78-2

Item Number

K139556

Grouped product items
SKU	Size	Availability	Price
K139556-100μg	100μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$549.90
K139556-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,089.90
K139556-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$7,896.90

Basic Description

Synonyms	(5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid \| AKOS030254879 \| (5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-
Specifications & Purity	≥97%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	K252B: an inhibitor of protein kinase A, C, G K-252b is a general, cell permeable protein kinase inhibitor which acts by binding to the ATP binding domain of the kinase. K-252b is a potent inhibitor of CaMKII (Ca2+/calmodulin kinase II), MYLK (myosin light chain kinase, Ki=0.147 μM), PKA (cAMP- dependent protein kinase, Ki=0.09 μM), PKC (protein kinase C, Ki=0.02 μM), and cGKI (cGMP-dependent protein kinase, Ki=0.1 μM). An antibiotic and a strong inhibitor of protein kinase C (PKC)

Names and Identifiers

IUPAC Name	(15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylic acid
INCHI	InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1
InChi Key	AMSOPBXQXSAAAC-PLZPTFKGSA-N
Canonical SMILES	CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Isomeric SMILES	C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
PubChem CID	9981344
Molecular Weight	453.5

Lot Number

Certificate Type

Date

Item

Certificate of Analysis

Sep 05, 2023

K139556

Solubility

Soluble in DMSO (1 mg/ml), DMF (1 mg/ml), and methanol (2 mg/ml).

Sensitivity

Light & Air Sensitive & Hygroscopic

Boil Point(°C)

769.82 °C at 760 mmHg

Melt Point(°C)

318.16°C

Solution Calculators

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Basic Description