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Kanamycin disulfate salt from Streptomyces kanamyceticus - aminoglycoside antibiotic, high purity , CAS No.64013-70-3

  • aminoglycoside antibiotic
Item Number
K475878
Grouped product items
SKUSizeAvailabilityPrice Qty
K475878-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$71.90
K475878-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$184.90
K475878-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$817.90
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Basic Description

Synonyms64013-70-3 | Kanamycin acid sulfate | Kanamycin A disulfate | Kanamycin A acid sulfate | Kanamycin disulfate | 1KF3N5C3AK | Kanamycin acid sulfate [WHO-IP] | UNII-1KF3N5C3AK | Kanamycini sulfas acidus [WHO-IP LATIN] | D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl
Specifications & Purityaminoglycoside antibiotic
Product Description

Description

Chemical structure: aminoglycosideKanamycin sulfate is a broad spectrum minoglycoside-antibiotic It is used as an additive in culture media for the isolation of group DStreptococcion Kanamycin Esculin Azide Agar (Mossel et al.) or for selection of transformed plant cells containing the neomycin phosphotransferase (for kanamycin resistance); on a kanamycin-medium. Kanamycin has been used for electrophysiological recordings of outer hair cells and inner hair cells. It is used to inhibit shoot regeneration from Siberian Elmleaf explants. It is recommended for use in cell culture applications at 100 mg/mL.


Preparation instructions

Kanamycin sulfate is soluble in water at 10 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.Kanamycin acid sulfate is prepared by solubilizing kanamycin sulfate in dilute sulfuric acid and drying. The sulfate content is approximately 25%.

Names and Identifiers

IUPAC Name (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
INCHI InChI=1S/C18H36N4O11.2H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;2*1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;2*(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;;/m1../s1
InChi Key OGTKIXVMLDAMNU-KNQICTBBSA-N
Canonical SMILES C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O.OS(=O)(=O)O
Isomeric SMILES C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O.OS(=O)(=O)O
WGK Germany 3
PubChem CID 24721551

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility H2O: 10mg/mL

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H360:May damage fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

References

1. Dale W Hailey,Brock Roberts,Kelly N Owens,Andrew K Stewart,Tor Linbo,Remy Pujol,Seth L Alper,Edwin W Rubel,David W Raible.  (2012-10-17)  Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone..  PLoS genetics,  8  ((10)): (e1002971-e1002971).  [PMID:23071446]
2. Adam C Palmer,Erdal Toprak,Michael Baym,Seungsoo Kim,Adrian Veres,Shimon Bershtein,Roy Kishony.  (2015-06-11)  Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes..  Nature communications,  6  (7385-7385).  [PMID:26060115]
3. Cicera R Lazzarotto,Nhu T Nguyen,Xing Tang,Jose Malagon-Lopez,Jimmy A Guo,Martin J Aryee,J Keith Joung,Shengdar Q Tsai.  (2018-10-21)  Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq..  Nature protocols,  13  ((11)): (2615-2642).  [PMID:30341435]
4. Joshua N Gustine,Matthew B Au,John R Haserick,Erik C Hett,Eric J Rubin,Frank C Gibson,Lingyi L Deng.  (2019-01-04)  Cell Wall Hydrolytic Enzymes Enhance Antimicrobial Drug Activity Against Mycobacterium..  Current microbiology,  76  ((4)): (398-409).  [PMID:30603964]
5. Lokender Kumar,John Brice,Linda Toberer,Judith Klein-Seetharaman,Daniel Knauss,Susanta K Sarkar.  (2019-03-27)  Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides..  PloS one,  14  ((3)): (e0214411-e0214411).  [PMID:30913239]
6. Dorin Harpaz,Boris Veltman,Yael Sadeh,Robert S Marks,Nirit Bernstein,Evgeni Eltzov.  (2020-12-11)  The effect of cannabis toxicity on a model microbiome bacterium epitomized by a panel of bioluminescent E.\xa0coli..  Chemosphere,  263  (128241-128241).  [PMID:33297188]
7. Michael G Leitner,Christian R Halaszovich,Dominik Oliver.  (2010-10-12)  Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate..  Molecular pharmacology,  79  ((1)): (51-60).  [PMID:20935082]
8. Victoria Hsiao,Yutaka Hori,Paul Wk Rothemund,Richard M Murray.  (2016-05-20)  A population-based temporal logic gate for timing and recording chemical events..  Molecular systems biology,  12  ((5)): (869-869).  [PMID:27193783]

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