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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K129289-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $94.90 | |
K129289-5g | 5g | In stock | $379.90 | |
K129289-25g | 25g | In stock | $1,710.90 |
Selective COX-1 inhibitor
Synonyms | Ketorolac tromethamine|74103-07-4|Ketorolac tris salt|Toradol|Acular|Ketorolac (tromethamine salt)|Acular LS|Ketorolac tromethamine salt|Acuvail|Lixidol|Ketorolac trometamol|Acular PF|Syntex|Dolac|SPRIX|Tarasyn|Godek|Acular Preservative Free|Tromethamine |
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Specifications & Purity | ≥99% |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Dry ice |
Action Type | INHIBITOR |
Mechanism of action | Cyclooxygenase inhibitor |
Product Description | Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC50 of 0.10 μM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC50 of > 100 μM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC50 of 0.025 μM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC50 of 0.039 μM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 μM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol;5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid |
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INCHI | InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2 |
InChi Key | BWHLPLXXIDYSNW-UHFFFAOYSA-N |
Canonical SMILES | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O |
Isomeric SMILES | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O |
WGK Germany | 3 |
RTECS | UY7759900 |
PubChem CID | 84003 |
Molecular Weight | 376.4 |
Reaxy-Rn | 6463165 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2203398 | Certificate of Analysis | May 13, 2024 | K129289 |
H2203402 | Certificate of Analysis | May 13, 2024 | K129289 |
G1516073 | Certificate of Analysis | Jan 17, 2023 | K129289 |
L2009180 | Certificate of Analysis | Oct 17, 2022 | K129289 |
Solubility | Soluble in ethanol (~7 mg/ml), DMF (~50 mg/ml), DMSO (~7 mg/ml), water (15 mg/ml), and methanol. |
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Sensitivity | light &Moisture sensitive |
Melt Point(°C) | 160-162°C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | UY7759900 |
Reaxy-Rn | 6463165 |
Merck Index | 5306 |
1. Bagayoko S et al.. (2021) Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology.. PLoS Pathog, 17 (9): (e1009927). [PMID:34516571] |