Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K288441-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $137.90 | |
K288441-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $216.90 | |
K288441-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $488.90 | |
K288441-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $771.90 | |
K288441-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,236.90 |
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Synonyms | 877874-85-6|KG5|KG 5|KG-5|2-(Methylthio)-6-[4-(5-{[3-(trifluoromethyl)phenyl]amino}-4H-1,2,4-triazol-3-yl)-phenoxy]-pyrimidin-4-amine|2-(Methylthio)-6-(4-(5-((3-(trifluoromethyl)phenyl)amino)-4H-1,2,4-triazol-3-yl)phenoxy)pyrimidin-4-amine|2-(Methylthio)- |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | PDGFRβand B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests ce |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine |
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INCHI | InChI=1S/C20H16F3N7OS/c1-32-19-26-15(24)10-16(27-19)31-14-7-5-11(6-8-14)17-28-18(30-29-17)25-13-4-2-3-12(9-13)20(21,22)23/h2-10H,1H3,(H2,24,26,27)(H2,25,28,29,30) |
InChi Key | CMYHZFCJPORPHY-UHFFFAOYSA-N |
Canonical SMILES | CSC1=NC(=CC(=N1)OC2=CC=C(C=C2)C3=NC(=NN3)NC4=CC=CC(=C4)C(F)(F)F)N |
Isomeric SMILES | CSC1=NC(=CC(=N1)OC2=CC=C(C=C2)C3=NC(=NN3)NC4=CC=CC(=C4)C(F)(F)F)N |
PubChem CID | 53328059 |
Molecular Weight | 459.45 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K2228335 | Certificate of Analysis | Aug 17, 2022 | K288441 |
K2228336 | Certificate of Analysis | Aug 17, 2022 | K288441 |
K2228337 | Certificate of Analysis | Aug 17, 2022 | K288441 |
K2228338 | Certificate of Analysis | Aug 17, 2022 | K288441 |
K2228371 | Certificate of Analysis | Aug 17, 2022 | K288441 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 45.94, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 45.94, Max Conc. mM: 100 |
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