Ki16425 - ≥98%, high purity , CAS No.355025-24-0, Antagonist of GPR87;Antagonist of LPA 1 receptor;Antagonist of LPA 2 receptor;Antagonist of LPA 3 receptor

Item Number

K126742

• Synonyms: Ki16425|355025-24-0|Ki-16425|Ki 16425|3-((4-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)benzyl)thio)propanoic acid|3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic aci
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Antagonist of the lysophosphatidic acid receptors LPA1and LPA3(Kivalues are 0.25 and 0.36μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator prot
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of GPR87;Antagonist of LPA 1 receptor;Antagonist of LPA 2 receptor;Antagonist of LPA 3 receptor

Product Description

Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively, shows no activity at LPA4, LPA5, LPA6.
A competitive inhibitor of EDG-2, EDG-4, and EDG-7.