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KML 29 - 96%, high purity , CAS No.1380424-42-9, Inhibitor of Monoacylglycerol lipase

Moligand™
≥96%

CAS#: 1380424-42-9
Formula: C₂₄H₂₁F₆NO₇
Molecular Weight: 549.42
PubChem CID: 71656212

Item Number

K287859

Grouped product items
SKU	Size	Availability	Price
K287859-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$61.90
K287859-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$103.90
K287859-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$234.90
K287859-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$416.90
K287859-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$757.90

Highly potent and selective MAGL inhibitor.

View related series

Monoacylglycerol lipase Inhibitor

Basic Description

Synonyms	KML29\|KML-29\|1380424-42-9\|1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate\|KML 29\|1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate\|GTPL9482\|CHEM
Specifications & Purity	Moligand™, ≥96%
Biochemical and Physiological Mechanisms	Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50> 50000 nM). Potently and select
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Monoacylglycerol lipase
Product Description	Product Describtion: KML29 is an extremely selective, orally active and irreversible inhibitor of MAGL with IC50 of 15 nM, 43 nM and 5.9 nM for mouse, rat and human MAGL, respectively.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

Discover Target: FAAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGLL Tchem Monoglyceride lipase 4 Activities

Discover Target: MGLL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
INCHI	InChI=1S/C24H21F6NO7/c25-23(26,27)20(24(28,29)30)38-21(32)31-7-5-13(6-8-31)22(33,14-1-3-16-18(9-14)36-11-34-16)15-2-4-17-19(10-15)37-12-35-17/h1-4,9-10,13,20,33H,5-8,11-12H2
InChi Key	SXHQLPHDBLTFPM-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC(C(F)(F)F)C(F)(F)F
Isomeric SMILES	C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC(C(F)(F)F)C(F)(F)F
Alternate CAS	1380424-42-9
PubChem CID	71656212
MeSH Entry Terms	1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo(d)(1,3)dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;KML29 compound
Molecular Weight	549.42

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
G2213034	Certificate of Analysis	Jun 01, 2022	K287859
G2213035	Certificate of Analysis	Jun 01, 2022	K287859
G2213068	Certificate of Analysis	Jun 01, 2022	K287859
G2213070	Certificate of Analysis	Jun 01, 2022	K287859
G2213114	Certificate of Analysis	Jun 01, 2022	K287859

References

1. Ignatowska-Jankowska BM, Ghosh S, Crowe MS, Kinsey SG, Niphakis MJ, Abdullah RA, Tao Q, O' Neal ST, Walentiny DM, Wiley JL et al.. (2014) In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.. Br J Pharmacol, 171 (6): (1392-407). [PMID:23848221]

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