KMUH(N-κ-maleimidoundecanoic acid hydrazide) , CAS No.K638935

Item Number

K638935

• Storage Temp: Store at 2-8°C,Desiccated
• Shipped In: Wet ice

Product Description

Product introduction：

KMUH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).

Features of KMUH:

• Reactive groups:maleimide andhydrazide
• Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
• Long (19.0A), sulfhydryl-to-aldehyde crosslinker with simple aliphatic spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
• Usesodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
• Use withEDC to conjugate primary amine of hydrazide group to carboxyl groups

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

• Reactive Moiety:Amine,Hydrazide,Maleimide

• Crosslinker Type:Heterobifunctional

• Form:Solid

• Spacer:Medium(10 to 30 Å)

• Labeling Method:Chemical Labeling

• Spacer Arm Length:19.0 Å