Calculate the mass, volume, or concentration required for a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K120134-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $78.90 | |
K120134-10mg | 10mg | In stock | $137.90 | |
K120134-25mg | 25mg | In stock | $276.90 | |
K120134-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $494.90 | |
K120134-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $890.90 |
Potent, selective BCRP inhibitor
Synonyms | 461054-93-3|Ko 143|Ko143|Ko-143|tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate|CHEMBL488910|(3S,6S,12AS)-1,2,3,4,6,7,12,12A-OCTAHYDRO-9-METHOXY-6-(2-METHYLPROPYL) |
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Specifications & Purity | 98% |
Storage Temp | Store at -20°C |
Shipped In | Dry ice |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of ABCG2 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate |
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INCHI | InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1 |
InChi Key | NXNRAECHCJZNRF-JBACZVJFSA-N |
Canonical SMILES | CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC |
Isomeric SMILES | CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC |
WGK Germany | 3 |
PubChem CID | 10322450 |
Molecular Weight | 469.57 (anhydrous basis) |
PubChem CID | 10322450 |
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CAS Registry No. | 461054-93-3 |
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Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Jul 07, 2023 | K120134 | |
Certificate of Analysis | Jun 04, 2022 | K120134 | |
Certificate of Analysis | Jun 04, 2022 | K120134 | |
Certificate of Analysis | Jun 04, 2022 | K120134 | |
Certificate of Analysis | Jun 04, 2022 | K120134 | |
Certificate of Analysis | Jun 04, 2022 | K120134 |
Solubility | DMSO: >10 mg/mL |
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Refractive Index | 1.6 |
Boil Point(°C) | ~689.8° C at 760 mmHg |
Melt Point(°C) | 294.92°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315,H319,H335 |
Precautionary Statements | P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319 |
WGK Germany | 3 |