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Ko 143 - 98%, high purity , CAS No.461054-93-3, Inhibitor of ABCG2

Specifications & Purity:  98%
Item Number
K120134
Grouped product items
SKUSizeAvailabilityPrice Qty
K120134-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$78.90
K120134-10mg
10mg
In stock
$137.90
K120134-25mg
25mg
In stock
$276.90
K120134-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$494.90
K120134-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$890.90

Potent, selective BCRP inhibitor

View related series
ABCG2 Inhibitor

Basic Description

Synonyms461054-93-3|Ko 143|Ko143|Ko-143|tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate|CHEMBL488910|(3S,6S,12AS)-1,2,3,4,6,7,12,12A-OCTAHYDRO-9-METHOXY-6-(2-METHYLPROPYL)
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionInhibitor of ABCG2

Associated Targets

ABCB1 Tchem Multidrug resistance protein 1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 50 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
INCHI InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1
InChi Key NXNRAECHCJZNRF-JBACZVJFSA-N
Canonical SMILES CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
Isomeric SMILES CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
WGK Germany 3
PubChem CID 10322450
Molecular Weight 469.57 (anhydrous basis)

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
I1916129Certificate of AnalysisJul 07, 2023 K120134
G2215464Certificate of AnalysisJun 04, 2022 K120134
G2215465Certificate of AnalysisJun 04, 2022 K120134
G2215466Certificate of AnalysisJun 04, 2022 K120134
G2215767Certificate of AnalysisJun 04, 2022 K120134
G2215776Certificate of AnalysisJun 04, 2022 K120134

Chemical and Physical Properties

SolubilityDMSO: >10 mg/mL
Refractive Index1.6
Boil Point(°C)~689.8° C at 760 mmHg
Melt Point(°C)294.92°C

Safety and Hazards(GHS)

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