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Kolliphor® HS 15 , CAS No.70142-34-6

Item Number
K487242
Grouped product items
SKUSizeAvailabilityPrice Qty
K487242-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$34.90
K487242-50g
50g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
K487242-250g
250g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$279.90
View related series
Nonionic surfactant Poly PEG

Basic Description

SynonymsSolutol® HS 15 | Macrogol (15)-hydroxystearate | Polyethylene glycol (15)-hydroxystearate | Polyoxyethylated 12-hydroxystearic acid
Legal InformationKolliphor is a registered trademark of BASFSolutol is a registered trademark of BASF SE
Product Description

Kolliphor® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).


Application:

Kolliphor® HS 15 has been used:

in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force

in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses

to dissolve finerenone for oral application in in vivo-studies


Advantages and Features:

Low histamine release for fewer side-effects

Offers thermal stability, suitable for heat sterilization      

Has lower hemolytic activity than other polyoxyethylene-based surfactants      

Allows to formulate poorly soluble APIs in oral and parenteral dosage forms

Names and Identifiers

Alternate CAS 61909-81-7、105109-85-1、6284-41-9
PubChem CID 135327775

Certificates

Certificate of Analysis(COA)

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16 results found

Lot NumberCertificate TypeDateItem
A2412165Certificate of AnalysisAug 02, 2024 K487242
H2412163Certificate of AnalysisAug 02, 2024 K487242
H2412164Certificate of AnalysisAug 02, 2024 K487242
D2402326Certificate of AnalysisMar 14, 2024 K487242
D2402327Certificate of AnalysisMar 14, 2024 K487242
D2402328Certificate of AnalysisMar 14, 2024 K487242
A2429210Certificate of AnalysisJan 23, 2024 K487242
A2429212Certificate of AnalysisJan 23, 2024 K487242
A2429213Certificate of AnalysisJan 23, 2024 K487242
A2415194Certificate of AnalysisJun 21, 2023 K487242
G2312953Certificate of AnalysisJun 21, 2023 K487242
G23131057Certificate of AnalysisJun 21, 2023 K487242
H2329095Certificate of AnalysisJun 21, 2023 K487242
J2331071Certificate of AnalysisJun 21, 2023 K487242
E2306118Certificate of AnalysisMar 25, 2023 K487242
E2306119Certificate of AnalysisMar 25, 2023 K487242

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Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H317:May cause an allergic skin reaction

H402:Harmful to aquatic life

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P363:Wash contaminated clothing before reuse.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Related Documents

References

1. J S Coon,W Knudson,K Clodfelter,B Lu,R S Weinstein.  (1991-02-01)  Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance..  Cancer research,  51  ((3)): (897-902).  [PMID:1988130]
2. Arnaud Vonarbourg,Catherine Passirani,Léa Desigaux,Emilie Allard,Patrick Saulnier,Olivier Lambert,Jean-Pierre Benoit,Bruno Pitard.  (2009-03-31)  The encapsulation of DNA molecules within biomimetic lipid nanocapsules..  Biomaterials,  30  ((18)): (3197-3204).  [PMID:19329183]
3. Emlyn Clay,Riccardo Patacchini,Marcello Trevisani,Delia Preti,Maria Pia Branà,Domenico Spina,Clive Page.  (2016-02-04)  Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs..  The Journal of pharmacology and experimental therapeutics,  357  ((1)): (73-83).  [PMID:26837703]
4. Lunzhi Yuan,Xuan Liu,Liang Zhang,Yali Zhang,Yao Chen,Xiaoling Li,Kun Wu,Jiali Cao,Wangheng Hou,Yuqiong Que,Jun Zhang,Hua Zhu,Quan Yuan,Qiyi Tang,Tong Cheng,Ningshao Xia.  (2018-08-12)  Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection..  Emerging microbes & infections,  ((1)): (144-144).  [PMID:30097574]
5. Alejandro Villar-Prados,Sherry Y Wu,Karem A Court,Shaolin Ma,Christopher LaFargue,Mamur A Chowdhury,Margaret I Engelhardt,Cristina Ivan,Prahlad T Ram,Ying Wang,Keith Baggerly,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Shyh Ming-Yang,David J Maloney,Makoto Yoshioka,Jeffrey W Strovel,Jason Roszik,Anil K Sood.  (2018-11-14)  Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4..  Molecular cancer therapeutics,  18  ((2)): (421-436).  [PMID:30420565]
6. Tariq Fellous,Fabrizia De Maio,Hilal Kalkan,Biagio Carannante,Serena Boccella,Stefania Petrosino,Sabatino Maione,Vincenzo Di Marzo,Fabio Arturo Iannotti.  (2020-02-18)  Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets..  Biochemical pharmacology,  175  (113859-113859).  [PMID:32061773]
7. MyeongHoon Yeon,Hojung Choi,Hee-Sook Jun.  (2020-05-02)  Preventive Effects of Schisandrin A, A Bioactive Component of Schisandra chinensis, on Dexamethasone-Induced Muscle Atrophy..  Nutrients,  12  ((5)):   [PMID:32354126]
8. Hailey I Kilian,Homan Kang,Nikhila Nyayapathi,Takeshi Fukuda,Eeswar Adluru,Huijuan Zhang,Breandan Quinn,Jun Xia,Hak Soo Choi,Jonathan F Lovell.  (2020-06-10)  Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window..  Biomaterials science,  ((15)): (4199-4205).  [PMID:32515752]
9. Li Gan,Yong Gan,Chunliu Zhu,Xinxin Zhang,Jiabi Zhu.  (2008-09-09)  Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results..  International journal of pharmaceutics,  365  ((1-2)): (143-149).  [PMID:18773948]
10. Jan C Frankowski,Kelly M DeMars,Abdullah S Ahmad,Kimberly E Hawkins,Changjun Yang,Jenna L Leclerc,Sylvain Doré,Eduardo Candelario-Jalil.  (2015-12-10)  Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke..  Scientific reports,  (17956-17956).  [PMID:26648273]
11. Elien Van Nuffel,Jens Staal,Griet Baudelet,Mira Haegman,Yasmine Driege,Tino Hochepied,Inna S Afonina,Rudi Beyaert.  (2020-04-29)  MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice..  EMBO reports,  21  ((7)): (e49237-e49237).  [PMID:32343482]
12. Liu, et al..  (2020)  YAP activity protects against endotoxemic acute lung injury by activating multiple mechanisms..  International Journal of Molecular Medicine,  46  (2235-2250).  [PMID:33125123]

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