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SKU

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Price

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K487242-5g

Available within 4-8 weeks(?)

$34.90

K487242-50g

50g

Available within 4-8 weeks(?)

$69.90

K487242-250g

250g

In stock

$279.90

Basic Description

Synonyms	Solutol® HS 15 \| Macrogol (15)-hydroxystearate \| Polyethylene glycol (15)-hydroxystearate \| Polyoxyethylated 12-hydroxystearic acid
Legal Information	Kolliphor is a registered trademark of BASFSolutol is a registered trademark of BASF SE
Product Description	Kolliphor® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety). Application： Kolliphor® HS 15 has been used: in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses to dissolve finerenone for oral application in in vivo-studies Advantages and Features： Low histamine release for fewer side-effects Offers thermal stability, suitable for heat sterilization Has lower hemolytic activity than other polyoxyethylene-based surfactants Allows to formulate poorly soluble APIs in oral and parenteral dosage forms

Names and Identifiers

Alternate CAS	61909-81-7、105109-85-1、6284-41-9
PubChem CID	135327775

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot Number	Certificate Type	Date	Item
A2412165	Certificate of Analysis	Aug 02, 2024	K487242
H2412163	Certificate of Analysis	Aug 02, 2024	K487242
H2412164	Certificate of Analysis	Aug 02, 2024	K487242
D2402326	Certificate of Analysis	Mar 14, 2024	K487242
D2402327	Certificate of Analysis	Mar 14, 2024	K487242
D2402328	Certificate of Analysis	Mar 14, 2024	K487242
A2429210	Certificate of Analysis	Jan 23, 2024	K487242
A2429212	Certificate of Analysis	Jan 23, 2024	K487242
A2429213	Certificate of Analysis	Jan 23, 2024	K487242
A2415194	Certificate of Analysis	Jun 21, 2023	K487242
G2312953	Certificate of Analysis	Jun 21, 2023	K487242
G23131057	Certificate of Analysis	Jun 21, 2023	K487242
H2329095	Certificate of Analysis	Jun 21, 2023	K487242
J2331071	Certificate of Analysis	Jun 21, 2023	K487242
E2306118	Certificate of Analysis	Mar 25, 2023	K487242
E2306119	Certificate of Analysis	Mar 25, 2023	K487242

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Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H317:May cause an allergic skin reaction H402:Harmful to aquatic life
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P363:Wash contaminated clothing before reuse. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Citations of This Product

1. Jun Li, Yangyang Yang, Xiumin Han, Jing Li, Mengxiao Tian, Wenjing Qi, Huniu An, Chuanchuan Wu, Yao Zhang, Shuai Han, Liping Duan, Weisi Wang, Wenbao Zhang. (2023) Oral Delivery of Anti-Parasitic Agent-Loaded PLGA Nanoparticles: Enhanced Liver Targeting and Improved Therapeutic Effect on Hepatic Alveolar Echinococcosis. International Journal of Nanomedicine, [PMID:37312930]

References

1. J S Coon,W Knudson,K Clodfelter,B Lu,R S Weinstein. (1991-02-01) Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.. Cancer research, 51 ((3)): (897-902). [PMID:1988130]
2. Arnaud Vonarbourg,Catherine Passirani,Léa Desigaux,Emilie Allard,Patrick Saulnier,Olivier Lambert,Jean-Pierre Benoit,Bruno Pitard. (2009-03-31) The encapsulation of DNA molecules within biomimetic lipid nanocapsules.. Biomaterials, 30 ((18)): (3197-3204). [PMID:19329183]
3. Emlyn Clay,Riccardo Patacchini,Marcello Trevisani,Delia Preti,Maria Pia Branà,Domenico Spina,Clive Page. (2016-02-04) Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.. The Journal of pharmacology and experimental therapeutics, 357 ((1)): (73-83). [PMID:26837703]
4. Lunzhi Yuan,Xuan Liu,Liang Zhang,Yali Zhang,Yao Chen,Xiaoling Li,Kun Wu,Jiali Cao,Wangheng Hou,Yuqiong Que,Jun Zhang,Hua Zhu,Quan Yuan,Qiyi Tang,Tong Cheng,Ningshao Xia. (2018-08-12) Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection.. Emerging microbes & infections, 7 ((1)): (144-144). [PMID:30097574]
5. Alejandro Villar-Prados,Sherry Y Wu,Karem A Court,Shaolin Ma,Christopher LaFargue,Mamur A Chowdhury,Margaret I Engelhardt,Cristina Ivan,Prahlad T Ram,Ying Wang,Keith Baggerly,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Shyh Ming-Yang,David J Maloney,Makoto Yoshioka,Jeffrey W Strovel,Jason Roszik,Anil K Sood. (2018-11-14) Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4.. Molecular cancer therapeutics, 18 ((2)): (421-436). [PMID:30420565]
6. Tariq Fellous,Fabrizia De Maio,Hilal Kalkan,Biagio Carannante,Serena Boccella,Stefania Petrosino,Sabatino Maione,Vincenzo Di Marzo,Fabio Arturo Iannotti. (2020-02-18) Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets.. Biochemical pharmacology, 175 (113859-113859). [PMID:32061773]
7. MyeongHoon Yeon,Hojung Choi,Hee-Sook Jun. (2020-05-02) Preventive Effects of Schisandrin A, A Bioactive Component of Schisandra chinensis, on Dexamethasone-Induced Muscle Atrophy.. Nutrients, 12 ((5)): [PMID:32354126]
8. Hailey I Kilian,Homan Kang,Nikhila Nyayapathi,Takeshi Fukuda,Eeswar Adluru,Huijuan Zhang,Breandan Quinn,Jun Xia,Hak Soo Choi,Jonathan F Lovell. (2020-06-10) Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window.. Biomaterials science, 8 ((15)): (4199-4205). [PMID:32515752]
9. Li Gan,Yong Gan,Chunliu Zhu,Xinxin Zhang,Jiabi Zhu. (2008-09-09) Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results.. International journal of pharmaceutics, 365 ((1-2)): (143-149). [PMID:18773948]
10. Jan C Frankowski,Kelly M DeMars,Abdullah S Ahmad,Kimberly E Hawkins,Changjun Yang,Jenna L Leclerc,Sylvain Doré,Eduardo Candelario-Jalil. (2015-12-10) Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.. Scientific reports, 5 (17956-17956). [PMID:26648273]
11. Elien Van Nuffel,Jens Staal,Griet Baudelet,Mira Haegman,Yasmine Driege,Tino Hochepied,Inna S Afonina,Rudi Beyaert. (2020-04-29) MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.. EMBO reports, 21 ((7)): (e49237-e49237). [PMID:32343482]
12. Liu, et al.. (2020) YAP activity protects against endotoxemic acute lung injury by activating multiple mechanisms.. International Journal of Molecular Medicine, 46 (2235-2250). [PMID:33125123]
13. Jun Li, Yangyang Yang, Xiumin Han, Jing Li, Mengxiao Tian, Wenjing Qi, Huniu An, Chuanchuan Wu, Yao Zhang, Shuai Han, Liping Duan, Weisi Wang, Wenbao Zhang. (2023) Oral Delivery of Anti-Parasitic Agent-Loaded PLGA Nanoparticles: Enhanced Liver Targeting and Improved Therapeutic Effect on Hepatic Alveolar Echinococcosis. International Journal of Nanomedicine, [PMID:37312930]

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Kolliphor® HS 15 , CAS No.70142-34-6