KRN-633 - ≥97%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.286370-15-8, Vascular endothelial growth factor receptor inhibitor

Item Number

K125907

Grouped product items
SKU	Size	Availability	Price
K125907-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$116.90
K125907-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$526.90
K125907-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$704.90

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Basic Description

Synonyms	KRN-633\|286370-15-8\|KRN 633\|KRN633\|K00589a\|VEGF receptor tyrosine kinase inhibitor III\|1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea\|CHEMBL406381\|1-{2-chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea\|E1V875I8DX\|VEGFR
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC50 values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Vascular endothelial growth factor receptor inhibitor
Note	卖完停产，不再备货
Product Description	KRN-633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor with IC50 of 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. An ATP-competitive inhibitor of VEGFR (Flt and Flk) kinase

Names and Identifiers

IUPAC Name	1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
INCHI	InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChi Key	VPBYZLCHOKSGRX-UHFFFAOYSA-N
Canonical SMILES	CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
Isomeric SMILES	CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
WGK Germany	3
PubChem CID	9549295
Molecular Weight	416.87

PubChem CID

ChEMBL Ligand

CAS Registry No.

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
D1810118	Certificate of Analysis	Oct 12, 2023	K125907
D1810119	Certificate of Analysis	Oct 07, 2023	K125907

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

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Basic Description