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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K649108-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $425.90 |
Flavonoids Chalcones Phenols Polyphenols
Synonyms | Kuraridine|KURAIDIN|kuraridin|34981-25-4|CHEMBL243362|Z399B8AG6Z|PIAPWPAWQGDOMN-SXAWMYDMSA-N|DTXSID501319126|GLXC-17536|BDBM50366787|AKOS040761957|MS-27861|HY-121381|CS-0081833|2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcon |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens . Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5xa0( PDE5 ) ( IC 50 =0.64 μM). |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens . Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 ( PDE5 ) ( IC 50 =0.64 μM) In Vitro Kuraridine shows potent inhibitory activity (IC 50 =0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal I GABA induced by a saturating GABA concentration (1 mM). Kuraridine induces a concentration–response curves for I GABA enhancement (EC 50 =4.0±2.4 μM) in Xenopus oocytes expressing GABA A receptors composed of α1, β2, and γ2S subunits. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PDE5 0.64 μM (IC 50 ) |
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IUPAC Name | (E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one |
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INCHI | InChI=1S/C26H30O6/c1-15(2)6-7-18(16(3)4)12-20-23(30)14-24(32-5)25(26(20)31)21(28)11-9-17-8-10-19(27)13-22(17)29/h6,8-11,13-14,18,27,29-31H,3,7,12H2,1-2,4-5H3/b11-9+/t18-/m1/s1 |
InChi Key | PIAPWPAWQGDOMN-SXAWMYDMSA-N |
Canonical SMILES | CC(=CCC(CC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=C(C=C(C=C2)O)O)O)C(=C)C)C |
Isomeric SMILES | CC(=CC[C@H](CC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=C(C=C(C=C2)O)O)O)C(=C)C)C |
Alternate CAS | 34981-25-4 |
PubChem CID | 44428631 |
MeSH Entry Terms | kuraridin |
Molecular Weight | 438.51 |
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Solubility | DMSO : ≥ 100 mg/mL (228.04 mM) |
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