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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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K649825-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $750.90 | |
K649825-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,300.90 |
Flavonoids Flavonones Phenols Polyphenols
Synonyms | Kushenol A|99217-63-7|(2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one|KushenolA|(-)-Kushenol A|S7LW4HSS6R|CHEMBL455679|CHEBI:197206|DTXSID701318374|HY-N2278|BDBM50377945|AKOS032948966|MS-27020|C |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent . Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC 50 and K i values of 1.1 μM and 0.4 μM, respectively. Kushenol |
Storage Temp | Protected from light,Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent . Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC 50 and K i values of 1.1 μM and 0.4 μM, respectively Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase ( IC 50 : 45 μM; K i : 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging In Vitro Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM. Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NSCLC cell lines, A549 and NCI-H226 Normal human lung epithelial: BEAS-2B Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: Exhibited considerable cytotoxic effects against NSCLC cells. Form:Solid IC50& Target:IC50: 1.1 μM (tyrosinase),45 μM (alpha-glucosidase) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one |
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INCHI | InChI=1S/C25H28O5/c1-14(2)9-10-16(15(3)4)11-18-20(27)12-21(28)24-22(29)13-23(30-25(18)24)17-7-5-6-8-19(17)26/h5-9,12,16,23,26-28H,3,10-11,13H2,1-2,4H3/t16-,23+/m1/s1 |
InChi Key | OGBMVWVBHWHRGD-MWTRTKDXSA-N |
Canonical SMILES | CC(=CCC(CC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=CC=C3O)C(=C)C)C |
Isomeric SMILES | CC(=CC[C@H](CC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC=CC=C3O)C(=C)C)C |
Alternate CAS | 99217-63-7 |
PubChem CID | 44563121 |
MeSH Entry Terms | kushenol A |
Molecular Weight | 408.49 |
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Solubility | DMSO : 100 mg/mL (244.80 mM; Need ultrasonic) |
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