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L-748,337 - ≥98%(HPLC), high purity , CAS No.244192-94-7, Antagonist of β 3-adrenoceptor

  • Moligand™
  • ≥98%(HPLC)
Item Number
L287872
Grouped product items
SKUSizeAvailabilityPrice Qty
L287872-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$45.90
L287872-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$145.90
L287872-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$265.90
L287872-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$534.90
L287872-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$999.90
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Selective β3antagonist

View related series
β3-adrenoceptor Antagonist

Basic Description

Synonyms244192-94-7|L-748,337|L748337|L-748337|N-[[3-[(2S)-2-HYDROXY-3-[[2-[4-[(PHENYLSULFONYL)AMINO]PHENYL]ETHYL]AMINO]PROPOXY]PHENYL]METHYL]-ACETAMIDE|L 748,337|CHEMBL4238084|(S)-N-(4-(2-(3-(3-(acetamidomethyl)phenoxy)-2-hydroxypropyl)amino)ethyl)phenylbenzenes
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsCompetitiveβ3-adrenoceptor antagonist that displays selectivity overβ1andβ2receptors (Kivalues are 4.0, 204 and 390 nM forβ3-,β2- andβ1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50= 6 nM). Reduces iNOS express
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of β 3-adrenoceptor

Associated Targets

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB3 Tclin Beta-3 adrenergic receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[[3-[(2S)-3-[2-[4-(benzenesulfonamido)phenyl]ethylamino]-2-hydroxypropoxy]phenyl]methyl]acetamide
INCHI InChI=1S/C26H31N3O5S/c1-20(30)28-17-22-6-5-7-25(16-22)34-19-24(31)18-27-15-14-21-10-12-23(13-11-21)29-35(32,33)26-8-3-2-4-9-26/h2-13,16,24,27,29,31H,14-15,17-19H2,1H3,(H,28,30)/t24-/m0/s1
InChi Key AWIONHVPTYTSHZ-DEOSSOPVSA-N
Canonical SMILES CC(=O)NCC1=CC(=CC=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
Isomeric SMILES CC(=O)NCC1=CC(=CC=C1)OC[C@H](CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
PubChem CID 10028830
Molecular Weight 497.61

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 49.76, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 4.98, Max Conc. mM: 10
SensitivityMoisture sensitive

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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