| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| L656264-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $85.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.\nIC50 value: 2 nM \nTarget: FPTase\nin vitro: L-778123 can completely inhibit Ki-Ras prenylation.L-778123 as a farnesylt |
| Storage Temp | Desiccated,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation.L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent.in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. |
| Canonical SMILES | C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl.Cl |
|---|---|
| Molecular Weight | 442.34 |
Enter Lot Number to search for COA:
