Click Here for 5% Off Your First Aladdin Purchase!

L-Cysteine S-sulfate - 98%, high purity , CAS No.1637-71-4

  • ≥98%
Item Number
L465016
Grouped product items
SKUSizeAvailabilityPrice Qty
L465016-5mg
5mg
In stock
$517.90
L465016-25mg
25mg
In stock
$1,782.90
L465016-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$6,415.90

Basic Description

SynonymsS-Sulfocysteine|L-Cysteine S-sulfate|1637-71-4|S-Sulphocysteine|S-Sulfo-L-cysteine|Cysteine-S-sulfate|Cysteine-S-sulfonate|Cysteinyl-S-sulfonate|Cysteinyl-S-sulfonic acid|S-sulpho-L-cysteine|L-Cysteine, S-sulfo-|Cysteine-S-Sulfonic Acid|3-(sulfosulfanyl)-
Specifications & Purity≥98%
Biochemical and Physiological MechanismsL-Cysteine S-sulfate (LCSS) is used as an NMDA glutamatergic receptor agonist. It serves as a substrate for cystine lyase(s).Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDOA Tbio Fructose-bisphosphate aldolase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2R)-2-amino-3-sulfosulfanylpropanoic acid
INCHI InChI=1S/C3H7NO5S2/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1
InChi Key NOKPBJYHPHHWAN-REOHCLBHSA-N
Canonical SMILES C(C(C(=O)O)N)SS(=O)(=O)O
Isomeric SMILES C([C@@H](C(=O)O)N)SS(=O)(=O)O
PubChem CID 115015
Molecular Weight 201.22
Beilstein 1726832

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
I2312411Certificate of AnalysisAug 23, 2023 L465016
I2312412Certificate of AnalysisAug 23, 2023 L465016
I2312413Certificate of AnalysisAug 23, 2023 L465016
I2312414Certificate of AnalysisAug 23, 2023 L465016
I2312415Certificate of AnalysisAug 23, 2023 L465016

Chemical and Physical Properties

Flash Point(°F)Not applicable
Flash Point(°C)Not applicable

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

RIDADR NONH for all modes of transport

Related Documents

References

1. J Dunlop,A Grieve,I Damgaard,A Schousboe,R Griffiths.  (1992-09-01)  Sulphur-containing excitatory amino acid-evoked Ca(2+)-independent release of D-[3H]aspartate from cultured cerebellar granule cells: the role of glutamate receptor activation coupled to reversal of the acidic amino acid plasma membrane carrier..  Neuroscience,  50  ((1)): (107-115).  [PMID:1357589]
2. F A Beemer,M Duran,S K Wadman,B P Cats.  (1985-04-01)  Absence of hepatic molybdenum cofactor. An inborn error of metabolism associated with lens dislocation..  Ophthalmic paediatrics and genetics,  ((3)): (191-195).  [PMID:3877898]
3. M Duran,G Aarsen,R H Fokkens,N M Nibbering,B P Cats,P K de Bree,S K Wadman.  (1981-03-19)  2-Mercaptoethanesulfonate-cysteine disulfide excretion following the administration of 2-mercaptoethanesulfonate--a pitfall in the diagnosis of sulfite oxidase deficiency..  Clinica chimica acta; international journal of clinical chemistry,  111  ((1)): (47-53).  [PMID:6784974]
4. F Orrego,S Villanueva.  (1993-10-01)  The chemical nature of the main central excitatory transmitter: a critical appraisal based upon release studies and synaptic vesicle localization..  Neuroscience,  56  ((3)): (539-555).  [PMID:7902967]
5. A Gorman,R Griffiths.  (1994-03-01)  Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors..  Neuroscience,  59  ((2)): (299-308).  [PMID:8008194]
6. H C Winter,T Ueda.  (1993-01-01)  Glutamate uptake system in the presynaptic vesicle: glutamic acid analogs as inhibitors and alternate substrates..  Neurochemical research,  18  ((1)): (79-85).  [PMID:8096630]
7. G L Arnold,C L Greene,J P Stout,S I Goodman.  (1993-10-01)  Molybdenum cofactor deficiency..  The Journal of pediatrics,  123  ((4)): (595-598).  [PMID:8410516]
8. H Zahn,H G Gattner.  (1997-01-01)  Hair sulfur amino acid analysis..  EXS,  78  (239-258).  [PMID:8962496]
9. R Griffiths,C Malcolm,L Ritchie,A Frandsen,A Schousboe,M Scott,P Rumsby,C Meredith.  (1997-06-15)  Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons..  Journal of neuroscience research,  48  ((6)): (533-542).  [PMID:9210523]
10. M P Washburn,W W Wells.  (1999-04-13)  Identification of the dehydroascorbic acid reductase and thioltransferase (Glutaredoxin) activities of bovine erythrocyte glutathione peroxidase..  Biochemical and biophysical research communications,  257  ((2)): (567-571).  [PMID:10198252]
11. W Xia,M Sandberg,S G Weber.  (2000-03-04)  Development of a liquid chromatographic method for picomole determination of S-sulfocysteine in trifluoroacetic acid extracts of neonatal rat brain..  Journal of pharmaceutical and biomedical analysis,  19  ((1-2)): (261-268).  [PMID:10698587]
12. E C Ramírez,J R Whitaker.  (2000-05-04)  Biochemical characterization of cystine lyase from broccoli (Brassica oleracea var. italica)..  Journal of agricultural and food chemistry,  47  ((6)): (2218-2225).  [PMID:10794613]
13. Claus Jacob,Gregory I Giles,Niroshini M Giles,Helmut Sies.  (2003-10-17)  Sulfur and selenium: the role of oxidation state in protein structure and function..  Angewandte Chemie (International ed. in English),  42  ((39)): (4742-4758).  [PMID:14562341]
14. Mohamed S Rashed,Amal A A Saadallah,Zuhair Rahbeeni,Wafaa Eyaid,Mohamed Z Seidahmed,Saad Al-Shahwan,Mustafa A M Salih,Mohammad E Osman,Mohamed Al-Amoudi,Lujane Al-Ahaidib,Minnie Jacob.  (2004-11-24)  Determination of urinary S-sulphocysteine, xanthine and hypoxanthine by liquid chromatography-electrospray tandem mass spectrometry..  Biomedical chromatography : BMC,  19  ((3)): (223-230).  [PMID:15558695]
15. Vural Küçükatay,Feyza Savcioğlu,Gülay Hacioğlu,Piraye Yargiçoğlu,Aysel Ağar.  (2005-02-01)  Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats..  Neurotoxicology and teratology,  27  ((1)): (47-54).  [PMID:15681120]
16. Emma E Hobson,Sumesh Thomas,Patricia M Crofton,Alison D Murray,John C S Dean,David Lloyd.  (2005-07-19)  Isolated sulphite oxidase deficiency mimics the features of hypoxic ischaemic encephalopathy..  European journal of pediatrics,  164  ((11)): (655-659).  [PMID:16025295]
17. Wen-Hann Tan,Florian S Eichler,Sadaf Hoda,Melissa S Lee,Hagit Baris,Catherine A Hanley,P Ellen Grant,Kalpathy S Krishnamoorthy,Vivian E Shih.  (2005-09-06)  Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature..  Pediatrics,  116  ((3)): (757-766).  [PMID:16140720]
18. Philippa B Mills,Emma J Footitt,Serkan Ceyhan,Paula J Waters,Cornelis Jakobs,Peter T Clayton,Eduard A Struys.  (2012-03-10)  Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency..  Journal of inherited metabolic disease,  35  ((6)): (1031-1036).  [PMID:22403017]
19. Abdel Ali Belaidi,Guenter Schwarz.  (2013-02-09)  Molybdenum cofactor deficiency: metabolic link between taurine and S-sulfocysteine..  Advances in experimental medicine and biology,  776  (13-19).  [PMID:23392866]
20. Glyn B Steventon,Samera Khan,Stephen C Mitchell.  (2018-06-09)  Comparison of the sulfur-oxygenation of cysteine and S-carboxymethyl-l-cysteine in human hepatic cytosol and the rôle of cysteine dioxygenase..  The Journal of pharmacy and pharmacology,  70  ((8)): (1069-1077).  [PMID:29882598]
21. Jasmina Zivanovic,Emilia Kouroussis,Joshua B Kohl,Bikash Adhikari,Biljana Bursac,Sonia Schott-Roux,Dunja Petrovic,Jan Lj Miljkovic,Daniel Thomas-Lopez,Youngeun Jung,Marko Miler,Sarah Mitchell,Verica Milosevic,Jose Eduardo Gomes,Moran Benhar,Bruno Gonzalez-Zorn,Ivana Ivanovic-Burmazovic,Roberta Torregrossa,James R Mitchell,Matthew Whiteman,Guenter Schwarz,Solomon H Snyder,Bindu D Paul,Kate S Carroll,Milos R Filipovic.  (2019-11-19)  Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration..  Cell metabolism,  30  ((6)): (1152-1170).  [PMID:31735592]
22. H J Olverman,A W Jones,K N Mewett,J C Watkins.  (1988-07-01)  Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes..  Neuroscience,  26  ((1)): (17-31).  [PMID:2901691]
23. J L Johnson,K V Rajagopalan.  (1995-01-01)  An HPLC assay for detection of elevated urinary S-sulphocysteine, a metabolic marker of sulphite oxidase deficiency..  Journal of inherited metabolic disease,  18  ((1)): (40-47).  [PMID:7623441]
24. I Maugras,J Gosteli,E Rapp,R Nyfeler.  (1995-02-01)  Peptide synthesis using novel S-sulfocysteine derivatives..  International journal of peptide and protein research,  45  ((2)): (152-156).  [PMID:7782163]
25. G A Qureshi,S M Baig.  (1993-02-01)  Application of high performance liquid chromatography in study of sulphur amino acid metabolism in uremic patients..  Biochemistry and molecular biology international,  29  ((2)): (359-368).  [PMID:8495218]
26. K Masuda,T Kamimura,M Kanesaki,K Ishii,A Imaizumi,T Sugiyama,Y Suzuki,E Ohtsuka.  (1996-01-01)  Efficient production of the C-terminal domain of secretory leukoprotease inhibitor as a thrombin-cleavable fusion protein in Escherichia coli..  Protein engineering,  ((1)): (101-106).  [PMID:9053897]
27. W Xia,M Sandberg,S G Weber.  (1998-04-01)  Comparison of anion-exchange and ion-modified reversed-phase liquid chromatography for the determination of S-sulfocysteine..  Journal of chromatography. B, Biomedical sciences and applications,  705  ((2)): (251-259).  [PMID:9521561]
28. G Touati,E Rusthoven,E Depondt,C Dorche,M Duran,B Heron,D Rabier,M Russo,J M Saudubray.  (2000-02-22)  Dietary therapy in two patients with a mild form of sulphite oxidase deficiency. Evidence for clinical and biological improvement..  Journal of inherited metabolic disease,  23  ((1)): (45-53).  [PMID:10682307]
29. R Nahum-Levy,D Lipinski,S Shavit,M Benveniste.  (2001-04-28)  Desensitization of NMDA receptor channels is modulated by glutamate agonists..  Biophysical journal,  80  ((5)): (2152-2166).  [PMID:11325718]
30. Anthony R Carroll,Anna Ngo,Ronald J Quinn,Joanne Redburn,John N A Hooper.  (2005-06-01)  Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp..  Journal of natural products,  68  ((5)): (804-806).  [PMID:15921437]
31. Tomoya Kinumi,Yukiyasu Shimomae,Ryuichi Arakawa,Yoshiro Tatsu,Yasushi Shigeri,Noboru Yumoto,Etsuo Niki.  (2005-12-31)  Effective detection of peptides containing cysteine sulfonic acid using matrix-assisted laser desorption/ionization and laser desorption/ionization on porous silicon mass spectrometry..  Journal of mass spectrometry : JMS,  41  ((1)): (103-112).  [PMID:16382481]
32. Abdul-Karim Abbas,Wanlin Xia,Mattias Tranberg,Holger Wigström,Stephen G Weber,Mats Sandberg.  (2007-09-04)  S-sulfo-cysteine is an endogenous amino acid in neonatal rat brain but an unlikely mediator of cysteine neurotoxicity..  Neurochemical research,  33  ((2)): (301-307).  [PMID:17764028]
33. L H Ngu,B Afroze,B C Chen,O Affandi,M Y Zabedah.  (2009-11-13)  Molybdenum cofactor deficiency in a Malaysian child..  Singapore medical journal,  50  ((10)): (e365-e367).  [PMID:19907877]
34. Cecilia Gotor,Consolación Alvarez,M Angeles Bermúdez,Inmaculada Moreno,Irene García,Luis C Romero.  (2010-08-12)  Low abundance does not mean less importance in cysteine metabolism..  Plant signaling & behavior,  ((8)): (1028-1030).  [PMID:20699647]
35. Takeshi Nakatani,Iwao Ohtsu,Gen Nonaka,Natthawut Wiriyathanawudhiwong,Susumu Morigasaki,Hiroshi Takagi.  (2012-05-23)  Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli..  Microbial cell factories,  11  (62-62).  [PMID:22607201]
36. Elke Prade,Anne Zeck,Fabian Stiefel,Andreas Unsoeld,David Mentrup,Erik Arango Gutierrez,Ingo H Gorr.  (2020-11-18)  Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network..  Biotechnology and bioengineering,  118  ((3)): (1091-1104).  [PMID:33200817]

Solution Calculators