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L-O-Phosphoserine - >98.0%(T), high purity , CAS No.407-41-0, Agonist of mGlu 4 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 7 receptor;Agonist of mGlu 8 receptor

Moligand™
≥98%(T)

CAS#: 407-41-0
Formula: C₃H₈NO₆P
Molecular Weight: 185.07
MDL number: MFCD00065935
PubChem CID: 68841

Item Number

S161191

Grouped product items
SKU	Size	Availability	Price
S161191-1g	1g	In stock	$17.90
S161191-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$67.90
S161191-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$203.90

Group III mGlu agonist

View related series

mGlu4 receptor Agonist mGlu6 receptor Agonist mGlu7 receptor Agonist mGlu8 receptor Agonist

Basic Description

Synonyms	O-phospho-L-serine\|Dexfosfoserine\|407-41-0\|phosphoserine\|L-O-Phosphoserine\|Fosforina\|L-SOP\|O-Phosphoserine\|L-Phosphoserine\|L-Serine O-phosphate\|PHOSPHONOSERINE\|3-phosphoserine\|H-Ser(PO3H2)-OH\|Dexfosfoserine [INN]\|seriphos\|L-serine-O-phosphate\|O-phosphono-
Specifications & Purity	Moligand™, ≥98%(T)
Biochemical and Physiological Mechanisms	Group III metabotropic glutamate receptor agonist; analog ofL-AP4. Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Storage Temp	Argon charged
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of mGlu 4 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 7 receptor;Agonist of mGlu 8 receptor

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA5A Tclin Carbonic anhydrase 5A, mitochondrial 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

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KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 0 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 0 Activities

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CA9 Tclin Carbonic anhydrase 9 0 Activities

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BLM Tchem Bloom syndrome protein 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM2 Tchem Metabotropic glutamate receptor 2 0 Activities

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GRM4 Tchem Metabotropic glutamate receptor 4 1 Activities

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GRM7 Tchem Metabotropic glutamate receptor 7 2 Activities

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GRM8 Tchem Metabotropic glutamate receptor 8 0 Activities

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FOLH1 Tclin Glutamate carboxypeptidase 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM6 Tchem Metabotropic glutamate receptor 6 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-phosphonooxypropanoic acid
INCHI	InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChi Key	BZQFBWGGLXLEPQ-REOHCLBHSA-N
Canonical SMILES	C(C(C(=O)O)N)OP(=O)(O)O
Isomeric SMILES	C([C@@H](C(=O)O)N)OP(=O)(O)O
PubChem CID	68841
Molecular Weight	185.07
Reaxy-Rn	1726826

PubChem CID

DrugBank Ligand

ChEBI

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

Wikipedia

RCSB PDB Ligand

DrugCentral Ligand

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
H2422459	Certificate of Analysis	Aug 01, 2024	S161191
H2422460	Certificate of Analysis	Aug 01, 2024	S161191
H2422461	Certificate of Analysis	Aug 01, 2024	S161191
K2217775	Certificate of Analysis	Aug 24, 2022	S161191
K2217776	Certificate of Analysis	Aug 24, 2022	S161191
I1813112	Certificate of Analysis	Jul 19, 2022	S161191
I1813111	Certificate of Analysis	Jul 19, 2022	S161191

Solubility

Solvent:water, Max Conc. mg/mL: 18.51, Max Conc. mM: 100

Sensitivity

Moisture sensitive.

Specific Rotation[α]

5° (C=2,H2O)

Melt Point(°C)

190°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
Reaxy-Rn	1726826
Merck Index	7363

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