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LarotrectinibFor - 97%, high purity , CAS No.1223403-58-4, Inhibitor of neurotrophic receptor tyrosine kinase 1

Moligand™
≥97%

CAS#: 1223403-58-4
Formula: C₂₁H₂₂F₂N₆O₂
Molecular Weight: 428.4
EC Number: 826-190-2
PubChem CID: 46188928

Item Number

L172696

Grouped product items
SKU	Size	Availability	Price
L172696-5mg	5mg	In stock	$90.90
L172696-10mg	10mg	In stock	$117.90
L172696-25mg	25mg	In stock	$265.90
L172696-50mg	50mg	In stock	$315.90
L172696-100mg	100mg	In stock	$474.90

View related series

neurotrophic receptor tyrosine kinase 1 Inhibitor

Basic Description

Synonyms	Larotrectinib\|LOXO-101\|1223403-58-4\|ARRY-470\|(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide\|LOXO 101\|Vitrakvi\|ARRY 470\|PF9462I9HX\|BAY2757556\|BAY-2757556\|UNII-PF9462I9HX\|LOXO101\|(3S)-N-
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of neurotrophic receptor tyrosine kinase 1

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK2 Tclin Activated CDC42 kinase 1 0 Activities

Discover Target: TNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALK Tclin ALK tyrosine kinase receptor 0 Activities

Discover Target: ALK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK2 Tclin BDNF/NT-3 growth factors receptor 4 Activities

Discover Target: NTRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 7 Activities

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK3 Tclin NT-3 growth factor receptor 4 Activities

Discover Target: NTRK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
INCHI	InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
InChi Key	NYNZQNWKBKUAII-KBXCAEBGSA-N
Canonical SMILES	C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F
Isomeric SMILES	C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F
Alternate CAS	1223403-58-4
PubChem CID	46188928
MeSH Entry Terms	(3S)-N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;ARRY-470;ARRY470;BAY-2757556;BAY2757556;larotrectinib;LOXO-101;LOXO101;N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-
Molecular Weight	428.4

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
F2204769	Certificate of Analysis	Dec 23, 2021	L172696
F22041046	Certificate of Analysis	Dec 20, 2021	L172696
F2204768	Certificate of Analysis	Dec 20, 2021	L172696
F2204813	Certificate of Analysis	Dec 20, 2021	L172696
F2204830	Certificate of Analysis	Dec 20, 2021	L172696

Pictogram(s)

GHS07

Signal

Warning

Hazard Statements

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

References

1. Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS et al.. (2018) Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.. N Engl J Med, 378 (8): (731-739). [PMID:29466156]
2. Scott LJ. (2019) Larotrectinib: First Global Approval.. Drugs, 79 (2): (201-206). [PMID:30635837]

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