| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| L655521-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $165.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk , Lyn, Btk and Txk respectivelyIC50 Value: 13 nM(Lck) Target: Src family kinaseLck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). |
| Canonical SMILES | OC1=CC=C(C)C(NC2=CC=NC(NC3=CC(C(N)=O)=CC=C3)=N2)=C1 |
|---|---|
| Molecular Weight | 335.36 |
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