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lenrispodun , CAS No.1160521-50-5, Inhibitor of phosphodiesterase 1B;Inhibitor of phosphodiesterase 4A

Moligand™

CAS#: 1160521-50-5
PubChem CID: 42639643

Item Number

L611485

Grouped product items
SKU	Size	Availability	Price	Qty
L611485-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
L611485-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90

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phosphodiesterase 1B Inhibitor phosphodiesterase 4A Inhibitor

Basic Description

Synonyms	ITI214 free base\|1160521-50-5\|Lenrispodun\|ITI-214 free base\|ITI-214\|Lenrispodun [USAN]\|ITI-214F\|ITI-214 (free base)\|3GBO34D1BE\|IC200214\|UNII-3GBO34D1BE\|PDE1-IN-1\|CHEMBL3769414\|WHO 11635\|IC-200214\|(11R,15S)-5-anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]meth
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of phosphodiesterase 1B;Inhibitor of phosphodiesterase 4A

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1 Activities

Discover Target: PDE4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE1B Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0 Activities

Discover Target: PDE1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(11R,15S)-5-anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one
INCHI	InChI=1S/C29H26FN7O/c1-35-28(38)25-26(31-20-7-3-2-4-8-20)36(34-27(25)37-23-11-5-10-22(23)33-29(35)37)17-18-13-15-19(16-14-18)21-9-6-12-24(30)32-21/h2-4,6-9,12-16,22-23,31H,5,10-11,17H2,1H3/t22-,23+/m1/s1
InChi Key	BBIPVJCGIASXJB-PKTZIBPZSA-N
Canonical SMILES	CN1C(=O)C2=C(N(N=C2N3C1=NC4C3CCC4)CC5=CC=C(C=C5)C6=NC(=CC=C6)F)NC7=CC=CC=C7
Isomeric SMILES	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CC=C(C=C5)C6=NC(=CC=C6)F)NC7=CC=CC=C7
Alternate CAS	1160521-50-5
PubChem CID	42639643
MeSH Entry Terms	2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta(4,5)imidazo(1,2-a)pyrazolo(4,3-e)pyrimidin-4-(2H)-one;ITI-214

PubChem CID

ChEMBL Ligand

CAS Registry No.

BindingDB Ligand

DrugBank Ligand

RCSB PDB Ligand

References

1. Li P, Zheng H, Zhao J, Zhang L, Yao W, Zhu H, Beard JD, Ida K, Lane W, Snell G et al.. (2016) Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.. J Med Chem, 59 (3): (1149-64). [PMID:26789933]
2. Wennogle LP, Hoxie H, Peng Y, Hendrick JP. (2017) Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction.. Adv Neurobiol, 17 (3): (349-384). [PMID:28956339]

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lenrispodun , CAS No.1160521-50-5, Inhibitor of phosphodiesterase 1B;Inhibitor of phosphodiesterase 4A

Basic Description

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1 Activities

PDE1B Tclin Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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