Lercanidipine hydrochloride hemihydrate - ≥98% (HPLC), high purity , Voltage-gated L-type calcium channel blocker, CAS No.132866-11-6, Voltage-gated L-type calcium channel blocker

Item Number

L122339

Grouped product items
SKU	Size	Availability	Price
L122339-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$53.90
L122339-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$205.90
L122339-200mg	200mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$423.90
L122339-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,908.90
L122339-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$8,586.90

CaV1.x blocker

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Basic Description

Synonyms	Lercanidipine hydrochloride\|132866-11-6\|Lercanidipine HCl\|Cardiovasc\|Corifeo\|Carmen\|Lercadip\|Lerzam\|Lercan\|LERCANIDIPINEHCL\|Rec-15/2375\|Lercanidipine (hydrochloride)\|100427-27-8\|3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-di
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	L-type Ca2+channel blocker that displays higher vascular selectivity than felodipine. Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive. Also exhibits anti-MERS-CoV activity in Vero cellsin vitro(IC50= 2.36 μM).
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	BLOCKER
Mechanism of action	Voltage-gated L-type calcium channel blocker
Note	200mg、1g、10mg卖完停产，不再备货
Product Description	Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine . A calcium channel protein inhibitor

Names and Identifiers

IUPAC Name	5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
INCHI	InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H
InChi Key	WMFYOYKPJLRMJI-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
Isomeric SMILES	CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
WGK Germany	3
PubChem CID	157917
UN Number	2811
Molecular Weight	657.2

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
J1515147	Certificate of Analysis	Jul 07, 2023	L122339
D2320771	Certificate of Analysis	Mar 15, 2023	L122339
D2320827	Certificate of Analysis	Mar 15, 2023	L122339
D2321125	Certificate of Analysis	Mar 15, 2023	L122339
D2321127	Certificate of Analysis	Mar 15, 2023	L122339
D2321760	Certificate of Analysis	Mar 15, 2023	L122339
H1806053	Certificate of Analysis	Jun 14, 2022	L122339

Solubility

Solvent:DMSO, Max Conc. mg/mL: 64.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 6.48, Max Conc. mM: 10

Sensitivity

Light and Moisture Sensitive

Melt Point(°C)

195 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H302:Harmful if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
Merck Index	5446

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Basic Description