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Leronlimab (anti-CCR5) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCR5/CD195, >95%, high purity, Human IgG4SP, Antibody of CCR5

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Application: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
  • Species reactivity(Reacts with): Human,Rhesus monkey
  • Isotype: Human IgG4SP
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab169252
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab169252-100μg
100μg
In stock
$89.90
Ab169252-1mg
1mg
In stock
$447.90
Ab169252-5mg
5mg
In stock
$1,227.90
Ab169252-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,917.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameLeronlimab (anti-CCR5) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CCR5/CD195, >95%, high purity, Human IgG4SP
SynonymsRecombinant Leronlimab Antibody; Leronlimab (anti-CCR5); PRO 140; Vyrologi; Leronlimab; AM4 7 antibody; C C chemokine receptor type 5 antibody; C C CKR 5 antibody; C-C chemokine receptor type 5 antibody; C-C CKR-5 antibody; C-C motif chemokine receptor 5
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityCCR5/CD195
ApplicationELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeANTAGONIST
Mechanism of actionAntibody of CCR5
Product Description

Leronlimab (anti-CCR5) is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.
In vitro
Leronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca2+ signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.
In vivo
In xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg 

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeHuman IgG4SP
Light Chain Typekappa
SDS-PAGE27.7 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 169.8 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
SourceCHO supernatant
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS674782-26-4

Images

Leronlimab (anti-CCR5) (Ab169252) - SEC
The purity of Leronlimab (anti-CCR5) (Ab169252) is more than 95% verified by HPLC.

Associated Targets

CCR5 Tclin C-C chemokine receptor type 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0303660Certificate of AnalysisMar 25, 2024 Ab169252
ZJ24F0303659Certificate of AnalysisMar 25, 2024 Ab169252
ZJ24F0303658Certificate of AnalysisMar 25, 2024 Ab169252

Related Documents

References

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