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Lesinurad - 98%, high purity , Solute carrier family 22 member 12 inhibitor, CAS No.878672-00-5, Solute carrier family 22 member 12 inhibitor

Moligand™
≥98%

CAS#: 878672-00-5
Formula: C₁₇H₁₄BrN₃O₂S
Molecular Weight: 404.28
PubChem CID: 53465279
PubChem SID: 488201641

Item Number

L126243

Grouped product items
SKU	Size	Availability	Price
L126243-5mg	5mg	In stock	$28.90
L126243-10mg	10mg	In stock	$48.90
L126243-25mg	25mg	In stock	$100.90
L126243-50mg	50mg	In stock	$163.90
L126243-100mg	100mg	In stock	$263.90
L126243-250mg	250mg	In stock	$594.90
L126243-1g	1g	In stock	$2,138.90
L126243-5g	5g	In stock	$9,622.90

View related series

Urate anion exchanger 1 Inhibitor

Basic Description

Synonyms	LESINURAD\|878672-00-5\|RDEA594\|RDEA 594\|Zurampic\|RDEA-594\|2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid\|UNII-09ERP08I3W\|Lesinurad free acid\|(+)-Lesinurad\|(-)-Lesinurad\|09ERP08I3W\|Lesinurad, (+)-\|Lesinurad, (-)-\|Lesinur
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been appr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Solute carrier family 22 member 12 inhibitor
Note	5mg、50mg、10mg卖完停产，不再备货
Product Description	Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC22A12 Tclin Solute carrier family 22 member 12 0 Activities

Discover Target: SLC22A12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC2A9 Tbio Solute carrier family 2, facilitated glucose transporter member 9 0 Activities

Discover Target: SLC2A9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC22A11 Tclin Solute carrier family 22 member 11 0 Activities

Discover Target: SLC22A11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488201641
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201641
IUPAC Name	2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
INCHI	InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
InChi Key	FGQFOYHRJSUHMR-UHFFFAOYSA-N
Canonical SMILES	C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O
Isomeric SMILES	C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O
PubChem CID	53465279
Molecular Weight	404.28

CAS Registry No.

PubChem CID

ChEMBL Ligand

DrugCentral Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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15 results found

Lot Number	Certificate Type	Date	Item
J1521092	Certificate of Analysis	Jun 09, 2023	L126243
E23061055	Certificate of Analysis	Apr 20, 2023	L126243
E23061057	Certificate of Analysis	Apr 20, 2023	L126243
E23061058	Certificate of Analysis	Apr 20, 2023	L126243
E23061060	Certificate of Analysis	Apr 20, 2023	L126243
E23061061	Certificate of Analysis	Apr 20, 2023	L126243
E23061063	Certificate of Analysis	Apr 20, 2023	L126243
E23061065	Certificate of Analysis	Apr 20, 2023	L126243
E23061066	Certificate of Analysis	Apr 20, 2023	L126243
E23061067	Certificate of Analysis	Apr 20, 2023	L126243
E23061068	Certificate of Analysis	Apr 20, 2023	L126243
E23061069	Certificate of Analysis	Apr 20, 2023	L126243
E23061070	Certificate of Analysis	Apr 20, 2023	L126243
E23061073	Certificate of Analysis	Apr 20, 2023	L126243
E23061082	Certificate of Analysis	Apr 20, 2023	L126243

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

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