Leupeptin hemisulfate salt - ≥90%(HPLC), high purity , CAS No.103476-89-7

  • ≥90%(HPLC)
Item Number
L111765
Grouped product items
SKUSizeAvailabilityPrice Qty
L111765-1mg
1mg
In stock
$22.90
L111765-5mg
5mg
In stock
$44.90
L111765-25mg
25mg
In stock
$106.90
L111765-100mg
100mg
In stock
$245.90

Reversible competitive serine/cysteine protease inhibitor

Basic Description

SynonymsAcetyl-L-leucyl-L-leucyl-L-argininal hemisulfate | Acetyl-Leu-Leu-Arg-al
Specifications & Purity≥90%(HPLC)
Biochemical and Physiological MechanismsReversible, competitive serine/cysteine protease inhibitor. Inhibits cathepsins B, H, L and S, calpain and trypsin. Orally active. Antioxidant and anti-inflammatory agent. Active in vivo and in vitro .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide;sulfuric acid
INCHI InChI=1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1
InChi Key CIPMKIHUGVGQTG-VFFZMTJFSA-N
Canonical SMILES CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
Isomeric SMILES CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
PubChem CID 2733491
Molecular Weight 475.59

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
J2425751Certificate of AnalysisOct 16, 2024 L111765
J2425752Certificate of AnalysisOct 16, 2024 L111765
J2425753Certificate of AnalysisOct 16, 2024 L111765
I2403506Certificate of AnalysisAug 21, 2024 L111765
I2403507Certificate of AnalysisAug 21, 2024 L111765
H2205278Certificate of AnalysisJun 11, 2024 L111765
H2205277Certificate of AnalysisMay 20, 2024 L111765
F2403067Certificate of AnalysisMay 17, 2024 L111765
F2403068Certificate of AnalysisMay 17, 2024 L111765
C2226315Certificate of AnalysisDec 15, 2023 L111765
C2226324Certificate of AnalysisDec 15, 2023 L111765
C2226334Certificate of AnalysisDec 15, 2023 L111765
C2226337Certificate of AnalysisDec 15, 2023 L111765
K1901185Certificate of AnalysisJun 05, 2023 L111765
H2111398Certificate of AnalysisMay 11, 2023 L111765
H2111399Certificate of AnalysisMay 11, 2023 L111765

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Chemical and Physical Properties

SolubilitySoluble in water, ethanol, dimethyl formamide and acetic acid.

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

Related Documents

Citations of This Product

1. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou.  (2019)  Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.  Experimental and Therapeutic Medicine,  17  (5): (3501-3508).  [PMID:30988730] [10.3892/etm.2019.7352]
2. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan.  (2017)  Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens.  JOURNAL OF ASIA-PACIFIC ENTOMOLOGY,  20  (1340).  [PMID:] [10.1016/j.aspen.2017.10.005]

References

1. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou.  (2019)  Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.  Experimental and Therapeutic Medicine,  17  (5): (3501-3508).  [PMID:30988730] [10.3892/etm.2019.7352]
2. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan.  (2017)  Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens.  JOURNAL OF ASIA-PACIFIC ENTOMOLOGY,  20  (1340).  [PMID:] [10.1016/j.aspen.2017.10.005]

Solution Calculators