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Levamisol hydrochloride - 99%, high purity , CAS No.16595-80-5

4 Citations

≥99%

CAS#: 16595-80-5
Formula: C₁₁H₁₂N₂S·HCl
Molecular Weight: 240.75
MDL number: MFCD00012675
PubChem CID: 27944
PubChem SID: 488183066

Item Number

L118865

Grouped product items
SKU	Size	Availability	Price
L118865-5g	5g	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$38.90
L118865-10g	10g	In stock	$66.90
L118865-25g	25g	In stock	$150.90
L118865-100g	100g	In stock	$542.90
L118865-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,442.90

Alkaline phosphatase inhibitor. Selective agonist at nematode nAChRs.

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Five-Membered Heterocyclic Compounds Pharmaceutical ingredients

Basic Description

Synonyms	(-)-Tetramisole hydrochloride \| BMK1-H6 \| HMS1568F05 \| Levomysol hydrochloride \| EINECS 240-654-6 \| Ergamisol (TN) (Janssen) \| Levamisole HCl \| Levasole Soluble Pig Wormer \| R 12564 \| Citarin L \| Levamisole hydrochloride [USAN:USP] \| LEVAMISOLE HYDROCHLOR
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Alkaline phosphatase inhibitor. Also a selective agonist at nematode nicotinic acetylcholine receptors (nAChRs). Displays anticancer, immunomodulatory and antiparasitic activity.
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)

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FTL Tbio Ferritin light chain (0 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

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POLI Tchem DNA polymerase iota (0 Activities)

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BLM Tchem Bloom syndrome protein (0 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALPI Tchem Intestinal-type alkaline phosphatase (0 Activities)

Discover Target: ALPI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (0 Activities)

Discover Target: ALPL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HOP-92 (41141 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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MDA-N (28205 Activities)

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Malme-3M (44254 Activities)

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MDA-MB-231 (73002 Activities)

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SNB-75 (44215 Activities)

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NCI-H226 (44470 Activities)

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Associated Targets(non-human)

Iap Intestinal alkaline phosphatase (419 Activities)

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Plasmodium falciparum (966862 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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FTL Ferritin light chain (43324 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

Pubchem Sid	488183066
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183066
IUPAC Name	(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
INCHI	InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
InChi Key	LAZPBGZRMVRFKY-HNCPQSOCSA-N
Canonical SMILES	C1CSC2=NC(CN21)C3=CC=CC=C3.Cl
Isomeric SMILES	C1CSC2=N[C@H](CN21)C3=CC=CC=C3.Cl
PubChem CID	27944
UN Number	2811
Packing Group	III
Molecular Weight	240.75

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
K1821064	Certificate of Analysis	Sep 19, 2022	L118865
K1821063	Certificate of Analysis	Sep 19, 2022	L118865
B2309175	Certificate of Analysis	Jun 22, 2022	L118865
B2309179	Certificate of Analysis	Jun 22, 2022	L118865
E2411022	Certificate of Analysis	Jun 22, 2022	L118865
H2205286	Certificate of Analysis	Jun 22, 2022	L118865
H2205299	Certificate of Analysis	Jun 22, 2022	L118865
H2205300	Certificate of Analysis	Jun 22, 2022	L118865
H2311030	Certificate of Analysis	Jun 22, 2022	L118865
C1810052	Certificate of Analysis	Jan 19, 2022	L118865

Chemical and Physical Properties

Solubility	Easily soluble in chloroform, insoluble in acetone
Specific Rotation[α]	-126 ° (C=1, H2O)
Melt Point(°C)	228-230°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H373:Causes damage to organs through prolonged or repeated exposure H412:Harmful to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.
Class	6.1
Merck Index	5459

FAQs and Articles

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Citations of This Product

1. Shuna Chen, Jiaxin Kang, Huanqing Zhu, Ziyi Han, Leyu Wang, Kaixi Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li. (2024) Tea seed saponins ameliorate cyclophosphamide-induced intestinal injury, immune disorder and gut microbial dysbiosis in mice. Food Bioscience, 57 (103504). [PMID:]
2. Anqi Xie, Hao Wan, Lei Feng, Boyun Yang, Yiqun Wan. (2023) Protective Effect of Anoectochilus formosanus Polysaccharide against Cyclophosphamide-Induced Immunosuppression in BALB/c Mice. Foods, 12 (9): (1910). [PMID:37174447]
3. Han Mengyao, Zhang Zhongshan, Li Xinyue, Tong Haibin, Xu Zhiguo, Ding Zikang, Yang Anquan, Xie Min, Wang Xiaomei. (2022) Effects of collagen peptides from Micropterus salmoides skin on oxidative damage induced by cyclophosphamide in mice. Frontiers in Nutrition, 9 [PMID:36407538]
4. Chao Han, Ying Wang, Ruiying Liu, Beibei Ran, Weidong Li. (2022) Structural characterization and protective effect of Lonicerae flos polysaccharide on cyclophosphamide-induced immunosuppression in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 230 (113174). [PMID:34999342]

References

1. Moukengue B et al.. (2019) Analysis of mRNA, miRNA, and DNA in Bone Cells by RT-qPCR and In Situ Hybridization.. Methods Mol Biol, 1914 (169-196). [PMID:30729465]
2. Wessely A et al.. (2019) Induction of ALP and MMP9 activity facilitates invasive behavior in heterogeneous human BMSC and HNSCC 3D spheroids.. FASEB J, (fj201900925R). [PMID:31366234]
3. Shuna Chen, Jiaxin Kang, Huanqing Zhu, Ziyi Han, Leyu Wang, Kaixi Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li. (2024) Tea seed saponins ameliorate cyclophosphamide-induced intestinal injury, immune disorder and gut microbial dysbiosis in mice. Food Bioscience, 57 (103504). [PMID:]
4. Anqi Xie, Hao Wan, Lei Feng, Boyun Yang, Yiqun Wan. (2023) Protective Effect of Anoectochilus formosanus Polysaccharide against Cyclophosphamide-Induced Immunosuppression in BALB/c Mice. Foods, 12 (9): (1910). [PMID:37174447]
5. Han Mengyao, Zhang Zhongshan, Li Xinyue, Tong Haibin, Xu Zhiguo, Ding Zikang, Yang Anquan, Xie Min, Wang Xiaomei. (2022) Effects of collagen peptides from Micropterus salmoides skin on oxidative damage induced by cyclophosphamide in mice. Frontiers in Nutrition, 9 [PMID:36407538]
6. Chao Han, Ying Wang, Ruiying Liu, Beibei Ran, Weidong Li. (2022) Structural characterization and protective effect of Lonicerae flos polysaccharide on cyclophosphamide-induced immunosuppression in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 230 (113174). [PMID:34999342]

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Levamisol hydrochloride - 99%, high purity , CAS No.16595-80-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator