Basic Description

Synonyms	LEVOFLOXACIN\|100986-85-4\|Levaquin\|Quixin\|(-)-Ofloxacin\|Cravit\|Iquix\|Tavanic\|Ofloxacin S-(-)-form\|Levofloxacine\|(S)-Ofloxacin\|L-Ofloxacin\|Levofloxacino\|Levofloxacinum\|Elequine\|Oftaquix\|Levofloxacin Anhydrous\|Floxacin\|Volequin\|Nofaxin\|(S)-(-)-Ofloxacin\|DR-3
Specifications & Purity	>98.0%(HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Product Description	Levofloxacin is a broad-spectrum antibiotic used in pharmacokinetic , antibiotic resistance , and resistance prevention studies. Antibiotic against bacterial respiratory tract infections.

Names and Identifiers

IUPAC Name	(2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
INCHI	InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
InChi Key	GSDSWSVVBLHKDQ-JTQLQIEISA-N
Canonical SMILES	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Isomeric SMILES	C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
RTECS	UU8815550
PubChem CID	149096
Molecular Weight	361.37
Reaxy-Rn	5385660

Database links

PubChem CID	149096
RCSB PDB Ligand	LFX
CAS Registry No.	100986-85-4
DrugBank Ligand	DB01137
ChEMBL Ligand	CHEMBL33
DrugCentral Ligand	1569
Antibiotic DB	2026

Certificates

Certificate of Analysis(COA)

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19 results found

Lot Number	Certificate Type	Date	Item
D2425289	Certificate of Analysis	Apr 11, 2024	L157745
D2425399	Certificate of Analysis	Apr 11, 2024	L157745
D2425401	Certificate of Analysis	Apr 11, 2024	L157745
D2425403	Certificate of Analysis	Apr 11, 2024	L157745
D2425405	Certificate of Analysis	Apr 11, 2024	L157745
I2320592	Certificate of Analysis	Sep 11, 2023	L157745
I2320591	Certificate of Analysis	Sep 11, 2023	L157745
I2320590	Certificate of Analysis	Sep 11, 2023	L157745
C2419106	Certificate of Analysis	Sep 11, 2023	L157745
I2320588	Certificate of Analysis	Sep 11, 2023	L157745
I2320587	Certificate of Analysis	Sep 11, 2023	L157745
I2320585	Certificate of Analysis	Sep 11, 2023	L157745
I2320586	Certificate of Analysis	Sep 11, 2023	L157745
I2202363	Certificate of Analysis	Jul 22, 2022	L157745
I2202367	Certificate of Analysis	Jul 22, 2022	L157745
I2202364	Certificate of Analysis	Jul 22, 2022	L157745
G2313240	Certificate of Analysis	Jul 22, 2022	L157745
D2320058	Certificate of Analysis	Jul 22, 2022	L157745
H2325046	Certificate of Analysis	Sep 13, 2021	L157745

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Chemical and Physical Properties

Solubility	Slightly soluble in water or methanol. Soluble in glacial acetic acid or dichloromethan
Sensitivity	light sensitive
Specific Rotation[α]	-66° (C=5,CHCl3)
Melt Point(°C)	224 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
RTECS	UU8815550
Reaxy-Rn	5385660
Merck Index	6771

References

1. Haas W, Pillar CM, Zurenko GE, Lee JC, Brunner LS, Morris TW. (2009) Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.. Antimicrob Agents Chemother, 53 (8): (3552-60). [PMID:19506065]
2. Bulik CC, Christensen H, Nicolau DP. (2010) In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance.. Antimicrob Agents Chemother, 54 (1): (557-9). [PMID:19917762]
3. Morrow BJ, He W, Amsler KM, Foleno BD, Macielag MJ, Lynch AS, Bush K. (2010) In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.. Antimicrob Agents Chemother, 54 (5): (1955-64). [PMID:20176911]

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SKU	Size	Availability	Price
L157745-5g	5g	In stock	$29.90
L157745-25g	25g	In stock	$105.90
L157745-100g	100g	In stock	$219.90
L157745-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$659.90

Levofloxacin - >98.0%(HPLC), high purity , CAS No.100986-85-4