Name: Levofloxacin - 10mM in DMSO, high purity , CAS No.100986-85-4(DMSO)
Price: 137.9 USD
Availability: InStock

Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotictopoisomerase IIandtopoisomerase IVinhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections. In vitro Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate\xa0activity\xa0against anaerobes. Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more\xa0active\xa0than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.\xa0Levofloxacin\xa0inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. Levofloxacin\xa0exhibits twofold greater\xa0inhibitory\xa0and\xa0bactericidal\xa0activities\xa0than ofloxacin\xa0against\xa0either extracellular or intracellular tubercle bacilli.\xa0 Levofloxacin\xa0has the least\xa0inhibitory\xa0effect on osteoblastic cell growth, with a 50%\xa0inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis. Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. In vivo Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin. Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥98%

Names and Identifiers

Canonical SMILES	CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F
Molecular Weight	361.37

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro 5%TFA 3.06 mg/mL (13.0 mM); DMSO: 0.5 mg/mL (2.12 mM); Water: Insoluble;

Citations of This Product

1. Xin Zhong, Meihuan Ji, Wenxin Wu, Caicai Lu, Wenping Liu, Fubin Jiang. (2024) Enhanced Degradation of Levofloxacin through Visible-Light-Driven Peroxymonosulfate Activation over CuInS2/g-C3N4 Heterojunctions. Nanomaterials, 14 (1): (74). [PMID:38202529]
2. Shanguo Zhang, Tianyi Jiang, Fang Han, Liangyu Cao, Ming Li, Zhenyou Ge, Haoxiu Sun, Hao Wu, Wenlong Wu, Nannan Zhou, Muhammad Luqman Akhtar, Hongyuan Jiang. (2024) A wearable self-powered microneedle system based on conductive drugs for infected wound healing: A new electrical stimulation delivery strategy. CHEMICAL ENGINEERING JOURNAL, 480 (148347). [PMID:]
3. Zihao Yang, Qiang An, Shuman Deng, Bohan Xu, Zheng Li, Shian Deng, Bin Zhao, Zhihong Ye. (2023) Efficient activation of peroxydisulfate by modified red mud biochar derived from waste corn straw for levofloxacin degradation: Efficiencies and mechanisms. Journal of Environmental Chemical Engineering, 11 (27): (111609). [PMID:19558367]
4. Ben-Qing Huang, Hong-Guang Cui, Tian-Yun Feng, Cai-Ling Yuan, Ai-Lian Chang, Ming-Lu Shao, Chi-Fan Zhu. (2024) Thin film composite polyamide nanofiltration membranes with interlayer constructed with core-shell structured polystyrene-polyacrylamide nanospheres for antibiotics separation. Journal of Water Process Engineering, 57 (23): (104550). [PMID:8570614]
5. Wenqing Yu, Fanming Meng, Hainan Wei, Han Zhang, Sheng Yao. (2024) Construction of double Z-scheme Ag3PO4/MOF-In2S3/Bi2S3 heterojunction by micro-Ag bridges for photocatalytic degradation of levofloxacin. APPLIED SURFACE SCIENCE, 648 (159010). [PMID:12036302]
6. Yanzhuo Zhang, Yutai Sun, Rui He, Jing Zhao, Jiqin Wang, Tonghuan Yu, Xiaozhuan Zhang, Alexandr V. Bildyukevich. (2024) Effects of excess sludge composting process, environmentally persistent free radicals, and microplastics on antibiotics degradation efficiency of aging biochar. BIORESOURCE TECHNOLOGY, 393 (15): (130070). [PMID:37984667]
7. Yanling Liu, Qihang Cen, Kaiming Fan, Airan Hu, Xu Yuan, Shengji Xia. (2024) Enhancing nanofiltration membrane selectivity between mineral salts and organic pollutants by sulfonic acid functionalization for drinking water treatment. JOURNAL OF MEMBRANE SCIENCE, 693 (122358). [PMID:]
8. Aiyuan Jia, Fangyuan Zhang, Yongsheng Zhao, Zhi Liu, Lu Xin, Mei Hong, Yangxue Li. (2024) Facile fabrication of shapeable three-component hydrogen-bonded covalent-organic aerogel as permeable reactive barrier material for efficient in-situ fluoroquinolone contaminated groundwater remediation. SEPARATION AND PURIFICATION TECHNOLOGY, 334 (126037). [PMID:]
9. Manlu Cheng, Xingyu Long, Ping Song, Zenghui Diao, Gang Song, Diyun Chen, Lingjun Kong. (2024) Co-catalytic of aluminosilicate stabilized cobalt for peroxymonosulfate activation to degrade levofloxacin. CHEMICAL ENGINEERING JOURNAL, 480 (147885). [PMID:]
10. Samreen Sadiq, Iltaf Khan, Muhammad Humayun, Ping Wu, Abbas Khan, Sohail Khan, Aftab Khan, Shoaib Khan, Amal Faleh Alanazi, Mohamed Bououdina. (2023) Synthesis of Metal–Organic Framework-Based ZIF-8@ZIF-67 Nanocomposites for Antibiotic Decomposition and Antibacterial Activities. ACS Omega, 8 (51): (49244–49258). [PMID:38162750]
11. Guangli Li, Xiaoman Qi, Jingtao Wu, Xuan Wan, Tianyu Wang, Ying Liu, Yuwei Chen, Yonghui Xia. (2024) Highly stable electrochemical sensing platform for the selective determination of pefloxacin in food samples based on a molecularly imprinted-polymer-coated gold nanoparticle/black phosphorus nanocomposite. FOOD CHEMISTRY, 436 (137753). [PMID:37862994]
12. Zhenping Liu, Jun Zhou, Xianfeng Wang, Jinsong Zhao, Peng Zhao, Yi Ma, Suyi Zhang, Danqun Huo, Changjun Hou, Kang Ren. (2024) Graphene oxide mediated CdSe quantum dots fluorescent aptasensor for high sensitivity detection of fluoroquinolones. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 305 (4): (123497). [PMID:37813087]
13. Ligui Wu, Qiaofeng Wu, Jingcheng Xu, Lingling Rong, Xiaoli Yu, Chen Cai, Xiangfeng Huang, Xiaoming Zou. (2023) Responses of antibiotic resistance genes in the enhanced biological phosphorus removal system under various antibiotics: Mechanisms and implications. SCIENCE OF THE TOTAL ENVIRONMENT, 905 (167247). [PMID:37739079]
14. Miao Li, Juan Li, Chencheng Qin, Xiaoai Guo, Hou Wang, Zhuotong Zeng, Xingzhong Yuan. (2023) Cuprous-mediated peroxymonosulfate activation for Fenton-like removal of micropollutants: The function of co-catalyst and the accelerated degradation mechanism. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 264 (1): (115435). [PMID:37722303]
15. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2024) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, 461 (132477). [PMID:37716268]
16. Yuxuan He, Yueming Zhu, Jin Qian, Peifang Wang, Yuhang Zhang, Kailin Xu, Bianhe Lu, Yin Liu, Junwei Shen. (2023) Revealing the crystal phase effect of CeO2 in spinel-based nanocatalysts toward the peroxymonosulfate activation for organics degradation. CHEMICAL ENGINEERING JOURNAL, 474 (145737). [PMID:]
17. Shengzhe Wang, Hongxia Lv, Chengyu Jin, Yu Wang, Huangzhao Wei, Chenglin Sun, Lian Yu, Lei Ma, Xiangnan Li, Xiaowei Liu. (2023) Electrocatalytic degradation of levofloxacin wastewater by Ru-Ti-Ni/CNT electrodes. CATALYSIS COMMUNICATIONS, 182 (106756). [PMID:]
18. Jiawen Xu, Xiumin Shi, Mingyue Yi, Yanze Chi, Shuang Guo, Zhu Mao, Bing Zhao, Young Mee Jung. (2023) Improved charge-transfer enhancement by codoping Mg/Zn into ZrO2 for quinolone antibiotic drug determination. APPLIED SURFACE SCIENCE, 639 (158256). [PMID:]
19. Sun Lei, Guo Hao, Liu Bingqing, Pan Zhilan, Wu Ning, Zhang Hao, Yang Wu. (2023) Ultrasensitive levofloxacin electrochemical biosensor based on semiconducting covalent organic framework/poly-L-cysteine/triangular Ag nanoplates modified glassy carbon electrode. MICROCHIMICA ACTA, 190 (9): (1-10). [PMID:37555996]
20. Zhizhuo Chai, Jingquan Wang, Yixue Dai, Erdeng Du, Hongguang Guo. (2023) Synergy between UV light and trichloroisocyanuric acid on methylisothiazolinone degradation: Performance, kinetics and degradation pathway.. ENVIRONMENTAL RESEARCH, 236 (116693). [PMID:37481058]
21. Yuanqian Xiong, Dong Zhang, Cuizhu Ye, Yu Wang, Xiangrui Deng, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Qianhui Gu, Ganhui Huang. (2023) Ultra-sensitive detection of ciprofloxacin hydrochloride in milk by molecularly imprinted electrochemical sensor based on S-CoFe-MOFs/AuNPs. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 122 (105439). [PMID:]
22. Chen Jiuyan, Zhang Qiang, Zhu Yuwei, Zhang Mengli, Zhu Yutong, Farooq Usman, Lu Taotao, Qi Zhichong, Chen Weifeng. (2023) Adsorption of fluoroquinolone antibiotics onto ferrihydrite under different anionic surfactants and solution pH. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (32): (78229-78242). [PMID:37269523]
23. Hang Lv, Yuandong Huo, Manlu Cheng, Zenghui Diao, Gang Song, Diyun Chen, Lingjun Kong. (2023) High yielded Co–C derived from polyester-Cobalt carbothermal reduction for efficient activation of peroxymonosulfate to degrade levofloxacin. CHEMOSPHERE, 335 (139020). [PMID:37247677]
24. Jing Lou, Jiutao An, Xiangyou Wang, Xiaonan Yang, Guanglu Lu, Liang Wang, Zitong Zhao. (2023) Enhanced degradation of oxytetracycline in aqueous solution by DBD plasma-coupled vacuum ultraviolet/ultraviolet (VUV/UVC) system. CHEMOSPHERE, 335 (139021). [PMID:37247680]
25. Zichen Yang, Guoqing Chen, Chaoqun Ma, Jiao Gu, Chun Zhu, Lei Li, Hui Gao. (2023) Magnetic Fe3O4@COF@Ag SERS substrate combined with machine learning algorithms for detection of three quinolone antibiotics: Ciprofloxacin, norfloxacin and levofloxacin. TALANTA, 263 (124725). [PMID:37270860]
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27. Nguyen Quang Tung, Do Thi Cam Van, Dam Xuan Thang, Nguyen Thi Kim An, Tran Thi Trang, Bui Dinh Nhi, Nguyen Phuong Thao, Le The Son, Nguyen Nhat Huy, Nguyen Trung Dung. (2023) Hydrothermal synthesis of CuCoFe layered double hydroxide and its performance in the degradation of antibiotics: Influencing factors, degradation pathways, and reaction mechanism. Journal of Environmental Chemical Engineering, 11 (110127). [PMID:]
28. Xuan Zhou, Jiaxin Li, Yuda Hu, Yaohui Wu, Yonghong Wang, Ge Ning. (2023) A novel colorimetric assay for sensitive detection of kanamycin based on the aptamer-regulated peroxidase-mimicking activity of Co3O4 nanoparticles. Analytical Methods, [PMID:37157837]
29. Jiuyan Chen, Bingyao Xu, Lulu Lu, Qiang Zhang, Taotao Lu, Usman Farooq, Weifeng Chen, Qian Zhou, Zhichong Qi. (2023) Insight into the inhibitory roles of ionic liquids in the adsorption of levofloxacin onto clay minerals. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 666 (131303). [PMID:]
30. Yuxuan He, Jin Qian, Peifang Wang, Taiping Xie, Dionysios D. Dionysiou, Bianhe Lu, Sijing Tang. (2023) Synergized selenium-vacancy heterogeneous interface and carbon nanotubes for insight into efficient oxidation of pollutants via photocatalytic peroxymonosulfate activation. APPLIED CATALYSIS B-ENVIRONMENTAL, 330 (122620). [PMID:]
31. Yongchang Tian, Rong Zhang, Binbin Guan, Yaowei Zhu, Li Chen. (2023) Oxydextran-based photodynamic antibacterial nanoplatform with broad-Spectrum antibacterial activity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 236 (123917). [PMID:36871681]
32. Yi Hou, Mengmeng Jin, Dan Sun, Junfeng Li, Ruiye Bi, Li Zhang, Songsong Zhu. (2023) Multifunctional inorganic/organic nanocomposite microspheres - reinventing eggs for bone repair applications. COMPOSITES PART B-ENGINEERING, 255 (110644). [PMID:]
33. Cheng Zhang, Mengna Liang, Congying Shao, Ziwei Li, Xue Cao, Yongxiang Wang, Yanan Wu, Shun Lu. (2023) Visual Detection and Sensing of Mercury Ions and Glutathione Using Fluorescent Copper Nanoclusters. ACS Applied Bio Materials, 6 (3): (1283–1293). [PMID:36788220]
34. Xiuying Liu, Qianna Xia, Jiao Zhou, Bowen Li, Shuaiqi Zhao, Long Chen, Aimal Khan, Xiaoxia Li, Aihua Xu. (2024) Morphology-dependent activation of hydrogen peroxide with Cu2O for tetracycline hydrochloride degradation in bicarbonate aqueous solution. Journal of Environmental Sciences, 137 (567). [PMID:37980040]
35. Wei Liu, Jin Zhang, Qun Kang, Hongbing Chen, Ru Feng. (2023) Enhanced photocatalytic degradation performance of In2O3/g-C3N4 composites by coupling with H2O2. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 252 (114611). [PMID:36753972]
36. Meilan Pan, Shuang-yin Tang-hu, Chenhao Ni, Haihua Chen, Bingjun Pan. (2023) Constructing Ti(III)-laden TiO2 nanotube arrays for electrochemical defluorination of levofloxacin. Journal of Environmental Chemical Engineering, 11 (109392). [PMID:]
37. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen. (2023) Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink. FOOD CHEMISTRY, 411 (135514). [PMID:36724609]
38. Cao Fang, Changsheng Shao, Shenhao Wang, Yahui Wu, Chao Liu, Qing Huang. (2023) Simultaneous removal of levofloxacin and sulfadiazine in water by dielectric barrier discharge (DBD) plasma: Enhanced performance and degradation mechanism. PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 171 (459). [PMID:]
39. Jingwei Yan, Lin Gong, Senyou Chai, Cong Guo, Wei Zhang, Hongyou Wan. (2023) ZIF-67 loaded lotus leaf-derived biochar for efficient peroxymonosulfate activation for sustained levofloxacin degradation. CHEMICAL ENGINEERING JOURNAL, 458 (141456). [PMID:]
40. Lanlan Liang, Peike Cao, Xin Qin, Shuai Wu, Haokun Bai, Shuo Chen, Hongtao Yu, Yan Su, Xie Quan. (2023) Oxygen vacancies-driven nonradical oxidation pathway of catalytic ozonation for efficient water decontamination. APPLIED CATALYSIS B-ENVIRONMENTAL, 325 (122321). [PMID:]
41. Jinling Xie, Lingrui Zhang, Xuan Luo, Li Huang, Xiaobo Gong, Jing Tian. (2023) Sulfur anchored on N-doped porous carbon as metal-free peroxymonosulfate activator for tetracycline hydrochloride degradation: Nonradical pathway mechanism, performance and biotoxicity. CHEMICAL ENGINEERING JOURNAL, 457 (141149). [PMID:]
42. Aiyuan Jia, Yongsheng Zhao, Zhi Liu, Fangyuan Zhang, Can Shi, Zhisheng Liu, Mei Hong, Yangxue Li. (2023) New insight into enhanced transport of multi-component porous covalent-organic polymers with alkyl chains as injection agents for levofloxacin removal in saturated sand columns. SCIENCE OF THE TOTAL ENVIRONMENT, 862 (160773). [PMID:36509275]
43. Sheng Sheng, Jingjing Fu, Siyuan Song, Yuxuan He, Jin Qian, Ziyang Yi. (2022) Enhanced electron transfer for activation of peroxymonosulfate via MoS2 modified iron-based perovskite. ENVIRONMENTAL TECHNOLOGY, [PMID:36250403]
44. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian. (2022) Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography. MARINE POLLUTION BULLETIN, 184 (114215). [PMID:36307947]
45. Ling Hu, Zhiwen Wang, Yingzhang Shi, Cheng Liu, Yidong Hou, Jinhong Bi, Ling Wu. (2022) Coordination activation enhanced photocatalytic performance for levofloxacin degradation over defect-rich WO3 nanosheets. Journal of Environmental Chemical Engineering, 10 (108738). [PMID:]
46. Xufei Li, Ting Chen, Yanling Qiu, Zhiliang Zhu, Hua Zhang, Daqiang Yin. (2023) Magnetic dual Z-scheme g-C3N4/BiVO4/CuFe2O4 heterojunction as an efficient visible-light-driven peroxymonosulfate activator for levofloxacin degradation. CHEMICAL ENGINEERING JOURNAL, 452 (139659). [PMID:]
47. Rui Wang, Peng Zhao, Ruiquan Yu, Jing Jiang, Ruifeng Liang, Gongyan Liu. (2022) Cost-efficient collagen fibrous aerogel cross-linked by Fe (III) /silver nanoparticle complexes for simultaneously degrading antibiotics, eliminating antibiotic-resistant bacteria, and adsorbing heavy metal ions from wastewater. SEPARATION AND PURIFICATION TECHNOLOGY, 303 (122209). [PMID:]
48. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:]
49. Jingwei Yan, Lin Gong, Senyou Chai, Cong Guo, Wei Zhang, Hongyou Wan. (2022) Insights into a newly discovered mechanism for 1O2 formation in a chlorine ion-mediated sulfate radical-advanced oxidation process system for levofloxacin degradation in an aqueous solution. SEPARATION AND PURIFICATION TECHNOLOGY, 302 (122016). [PMID:]
50. Ming Liu, Ran Cen, Ji-Hong Lu, Tie-Hong Meng, Chun-Rong Li, Carl Redshaw, Timothy J. Prior, Zhu Tao, Xin Xiao. (2022) Cucurbit[6]uril-based carbon dots for recognizing L-tryptophan and capecitabine. Materials Chemistry Frontiers, 6 (19): (2859-2868). [PMID:]
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56. Tingting Song, Xiaoyan Meng, Huayu Wang, Chao Zhang, Ming Ge. (2022) Visible-LED-light-driven photocatalytic activation of peroxydisulfate by magnetic ZnFe2O4/Ag nanocomposite for efficient tetracycline degradation. SEPARATION AND PURIFICATION TECHNOLOGY, 297 (121474). [PMID:]
57. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
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References

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2. Shanguo Zhang, Tianyi Jiang, Fang Han, Liangyu Cao, Ming Li, Zhenyou Ge, Haoxiu Sun, Hao Wu, Wenlong Wu, Nannan Zhou, Muhammad Luqman Akhtar, Hongyuan Jiang. (2024) A wearable self-powered microneedle system based on conductive drugs for infected wound healing: A new electrical stimulation delivery strategy. CHEMICAL ENGINEERING JOURNAL, 480 (148347). [PMID:]
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Levofloxacin - 10mM in DMSO, high purity , CAS No.100986-85-4(DMSO)