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Levofloxacin - 10mM in DMSO, high purity , CAS No.100986-85-4(DMSO)

114 Citations
Item Number
L407938
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L407938-1ml
1ml
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Topo II Selective Inhibitors | Activators

Basic Description

Specifications & PurityMoligand™, 10mM in DMSO
Biochemical and Physiological MechanismsLevofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Information

Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotictopoisomerase IIandtopoisomerase IVinhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
In vitro

Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate\xa0activity\xa0against anaerobes. Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more\xa0active\xa0than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.\xa0Levofloxacin\xa0inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. Levofloxacin\xa0exhibits twofold greater\xa0inhibitory\xa0and\xa0bactericidal\xa0activities\xa0than ofloxacin\xa0against\xa0either extracellular or intracellular tubercle bacilli.\xa0 Levofloxacin\xa0has the least\xa0inhibitory\xa0effect on osteoblastic cell growth, with a 50%\xa0inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis. Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells.

In vivo

Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Names and Identifiers

Canonical SMILES CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F
Molecular Weight 361.37

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro 5%TFA 3.06 mg/mL (13.0 mM); DMSO: 0.5 mg/mL (2.12 mM); Water: Insoluble;

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Zihao Yang, Qiang An, Shuman Deng, Bohan Xu, Zheng Li, Shian Deng, Bin Zhao, Zhihong Ye.  (2023)  Efficient activation of peroxydisulfate by modified red mud biochar derived from waste corn straw for levofloxacin degradation: Efficiencies and mechanisms.  Journal of Environmental Chemical Engineering,  11  (27): (111609).  [PMID:19558367] [10.1016/j.jece.2023.111609]
2. Ben-Qing Huang, Hong-Guang Cui, Tian-Yun Feng, Cai-Ling Yuan, Ai-Lian Chang, Ming-Lu Shao, Chi-Fan Zhu.  (2024)  Thin film composite polyamide nanofiltration membranes with interlayer constructed with core-shell structured polystyrene-polyacrylamide nanospheres for antibiotics separation.  Journal of Water Process Engineering,  57  (23): (104550).  [PMID:8570614] [10.1016/j.jwpe.2023.104550]
3. Wenqing Yu, Fanming Meng, Hainan Wei, Han Zhang, Sheng Yao.  (2024)  Construction of double Z-scheme Ag3PO4/MOF-In2S3/Bi2S3 heterojunction by micro-Ag bridges for photocatalytic degradation of levofloxacin.  APPLIED SURFACE SCIENCE,  648  (159010).  [PMID:12036302] [10.1016/j.apsusc.2023.159010]
4. Xin Zhong, Meihuan Ji, Wenxin Wu, Caicai Lu, Wenping Liu, Fubin Jiang.  (2024)  Enhanced Degradation of Levofloxacin through Visible-Light-Driven Peroxymonosulfate Activation over CuInS2/g-C3N4 Heterojunctions.  Nanomaterials,  14  (1): (74).  [PMID:38202529] [10.3390/nano14010074]
5. Shanguo Zhang, Tianyi Jiang, Fang Han, Liangyu Cao, Ming Li, Zhenyou Ge, Haoxiu Sun, Hao Wu, Wenlong Wu, Nannan Zhou, Muhammad Luqman Akhtar, Hongyuan Jiang.  (2024)  A wearable self-powered microneedle system based on conductive drugs for infected wound healing: A new electrical stimulation delivery strategy.  CHEMICAL ENGINEERING JOURNAL,  480  (148347).  [PMID:] [10.1016/j.cej.2023.148347]
6. Yanling Liu, Qihang Cen, Kaiming Fan, Airan Hu, Xu Yuan, Shengji Xia.  (2024)  Enhancing nanofiltration membrane selectivity between mineral salts and organic pollutants by sulfonic acid functionalization for drinking water treatment.  JOURNAL OF MEMBRANE SCIENCE,  693  (122358).  [PMID:] [10.1016/j.memsci.2023.122358]
7. Aiyuan Jia, Fangyuan Zhang, Yongsheng Zhao, Zhi Liu, Lu Xin, Mei Hong, Yangxue Li.  (2024)  Facile fabrication of shapeable three-component hydrogen-bonded covalent-organic aerogel as permeable reactive barrier material for efficient in-situ fluoroquinolone contaminated groundwater remediation.  SEPARATION AND PURIFICATION TECHNOLOGY,  334  (126037).  [PMID:] [10.1016/j.seppur.2023.126037]
8. Manlu Cheng, Xingyu Long, Ping Song, Zenghui Diao, Gang Song, Diyun Chen, Lingjun Kong.  (2024)  Co-catalytic of aluminosilicate stabilized cobalt for peroxymonosulfate activation to degrade levofloxacin.  CHEMICAL ENGINEERING JOURNAL,  480  (147885).  [PMID:] [10.1016/j.cej.2023.147885]
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17. Shengzhe Wang, Hongxia Lv, Chengyu Jin, Yu Wang, Huangzhao Wei, Chenglin Sun, Lian Yu, Lei Ma, Xiangnan Li, Xiaowei Liu.  (2023)  Electrocatalytic degradation of levofloxacin wastewater by Ru-Ti-Ni/CNT electrodes.  CATALYSIS COMMUNICATIONS,  182  (106756).  [PMID:] [10.1016/j.catcom.2023.106756]
18. Jiawen Xu, Xiumin Shi, Mingyue Yi, Yanze Chi, Shuang Guo, Zhu Mao, Bing Zhao, Young Mee Jung.  (2023)  Improved charge-transfer enhancement by codoping Mg/Zn into ZrO2 for quinolone antibiotic drug determination.  APPLIED SURFACE SCIENCE,  639  (158256).  [PMID:] [10.1016/j.apsusc.2023.158256]
19. Sun Lei, Guo Hao, Liu Bingqing, Pan Zhilan, Wu Ning, Zhang Hao, Yang Wu.  (2023)  Ultrasensitive levofloxacin electrochemical biosensor based on semiconducting covalent organic framework/poly-L-cysteine/triangular Ag nanoplates modified glassy carbon electrode.  MICROCHIMICA ACTA,  190  (9): (1-10).  [PMID:37555996] [10.1007/s00604-023-05866-0]
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36. Meilan Pan, Shuang-yin Tang-hu, Chenhao Ni, Haihua Chen, Bingjun Pan.  (2023)  Constructing Ti(III)-laden TiO2 nanotube arrays for electrochemical defluorination of levofloxacin.  Journal of Environmental Chemical Engineering,  11  (109392).  [PMID:] [10.1016/j.jece.2023.109392]
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38. Cao Fang, Changsheng Shao, Shenhao Wang, Yahui Wu, Chao Liu, Qing Huang.  (2023)  Simultaneous removal of levofloxacin and sulfadiazine in water by dielectric barrier discharge (DBD) plasma: Enhanced performance and degradation mechanism.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  171  (459).  [PMID:] [10.1016/j.psep.2023.01.040]
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43. Sheng Sheng, Jingjing Fu, Siyuan Song, Yuxuan He, Jin Qian, Ziyang Yi.  (2022)  Enhanced electron transfer for activation of peroxymonosulfate via MoS2 modified iron-based perovskite.  ENVIRONMENTAL TECHNOLOGY,      [PMID:36250403] [10.1080/09593330.2022.2137438]
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