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Targets
Kinases
CAMK:Calcium/calmodulin-dependent protein kinases
LGB321 , CAS No.L611520, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase

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LGB321 , CAS No.L611520, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase

Moligand™

PubChem CID: 46179018

Item Number

L611520

Grouped product items
SKU	Size	Availability	Price	Qty
L611520-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
L611520-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

Pim-1 proto-oncogene，serine/threonine kinase Inhibitor Pim-2 proto-oncogene，serine/threonine kinase Inhibitor Pim-3 proto-oncogene，serine/threonine kinase Inhibitor

Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase

Associated Targets

PIM1 Tchem Serine/threonine-protein kinase pim-1 2 Activities

Discover Target: PIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM2 Tchem Serine/threonine-protein kinase pim-2 2 Activities

Discover Target: PIM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM3 Tchem Serine/threonine-protein kinase pim-3 2 Activities

Discover Target: PIM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
INCHI	InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1
InChi Key	ODZZYKUYGVLOTQ-ONJZCGHCSA-N
Canonical SMILES	C[C@H]1CN(C[C@H]([C@@H]1O)N)c1ccncc1NC(=O)c1ccc(c(n1)c1c(F)cccc1F)F
Isomeric SMILES	C[C@H]1CN(C[C@H]([C@@H]1O)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F
PubChem CID	46179018

Database links

PubChem CID	46179018
ChEMBL Ligand	CHEMBL3105022
BindingDB Ligand	106896
RCSB PDB Ligand	2HX

Certificates

Certificate of Analysis(COA)

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References

1. Garcia PD, Langowski JL, Wang Y, Chen M, Castillo J, Fanton C, Ison M, Zavorotinskaya T, Dai Y, Lu J et al.. (2014) Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.. Clin Cancer Res, 20 (7): (1834-45). [PMID:24474669]

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