Lintuzumab (anti-CD33) is a humanized monoclonal antibody that targets CD33, a 67-kDa cell surface glycoprotein expressed on most myeloid leukemia cells. Purity>95% (SDS-PAGE&SEC) Endotoxin Level < 0.01EU/μg
Product Properties
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
145.24 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
166089-32-3
Images
Lintuzumab (anti-CD33) (Ab175581) - Flow Cytometry Flow Cytometry analysis of human peripheral blood monocytes labelling CD33 with Lintuzumab (anti-CD33) (Ab175581) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Lintuzumab (anti-CD33) (Ab175581) - Flow Cytometry Flow Cytometry analysis of human peripheral blood monocytes labelling CD33 (red) with Lintuzumab (anti-CD33) (Ab175581) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Lintuzumab (anti-CD33) (Ab175581) - SEC The purity of Lintuzumab (anti-CD33) (Ab175581) is more than 95% verified by HPLC.
1.Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD. (1999) The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.. J Biol Chem, 274 (17):(11505-12). [PMID:10206955]
2.Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.. Eur J Immunol, 29 (11):(3440-9). [PMID:10556798]
3.Ferlazzo G, Spaggiari GM, Semino C, Melioli G, Moretta L. (2000) Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors.. Eur J Immunol, 30 (3):(827-33). [PMID:10741398]
4.Paul SP, Taylor LS, Stansbury EK, McVicar DW. (2000) Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.. Blood, 96 (2):(483-90). [PMID:10887109]
5.Caron PC, Co MS, Bull MK, Avdalovic NM, Queen C, Scheinberg DA. (1992) Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies.. Cancer Res, 52 (24):(6761-7). [PMID:1458463]
6.Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, de Tailly PD, Bulabois B, Poulet J, Kuhlein E et al.. (2005) Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells.. Blood, 105 (3):(1256-64). [PMID:15388576]
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