Lipopolysaccharide, E. coli 055:B5 - purified by trichloroacetic acid extraction, high purity , CAS No.93572-42-0

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  • purified by trichloroacetic acid extraction
Item Number
L386714
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L386714-5mg
5mg
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L386714-10mg
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25mg
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Discover Lipopolysaccharide, E. coli 055:B5 by Aladdin Scientific in purified by trichloroacetic acid extraction for only $66.90. Available - in Ligands at Aladdin Scientific. a component of the cell wall of Gram-negative bacteria and Specific activator of Toll-like receptor (TLR) 4. Tags: .

Basic Description

Specifications & Puritypurified by trichloroacetic acid extraction
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

Lipopolysaccharide,|E. coli|O55:B5 is a component of the cell wall of the O55:B5 serotype of the Gram-negative bacteria,|Escherichia coli|. Lipopolysaccharides (LPS) are made up of a hydrophobic lipid, a hydrophilic core polysaccharide chain and a hydrophilic O-antigenic polysaccharide side chain. LPS molecules contribute to the outer integrity of the cell membrane, protect the cell against bile salts and lipophilic antibiotics, and act as endotoxins in animals. LPS induces a strong immune response by binding to the CD14/TLR4/MD2 receptor complex, which promotes the secretion of pro-inflammatory cytokines. LPS is also an exogenous pyrogen. LPS O55:B5 has been derived from a serotype of|E. coli|O55:B5, which is part of a subdivision based on the O antigen component of LPS. Lipopolysaccharide, E. coli O55:B5 is a form of lipopolysaccharide (LPS) extracted from wild-type S-form E. coli serotype O55:B5. Lipopolysaccharide, E. coli O55:B5 is commonly used to activate toll-like receptor 4 (TLR4) on leukocytes, eliciting inflammatory signaling in isolated cells and in vivo.1,2,3,4 Lipopolysaccharide, E. coli O55:B5 includes three regions, the O-antigenic polysaccharide chain, the core oligosaccharide, and lipid A. Lipopolysaccharide, E. coli O55:B5 stimulates the activity of inducible nitric oxide synthase. Lipopolysaccharide, E. coli O55:B5 induces apoptosis in mouse thymus and swine lymphocytes. Lipopolysaccharide, E. coli O55:B5 is also known as LPS. Lipopolysaccharide, E. coli O55:B5is a component of the cell wall of Gram-negative bacteria and Specific activator of Toll-like receptor (TLR) 4.

Usage:

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

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18 results found

Lot NumberCertificate TypeDateItem
E2417252Certificate of AnalysisApr 18, 2024 L386714
E2417232Certificate of AnalysisApr 18, 2024 L386714
D2407378Certificate of AnalysisMar 09, 2024 L386714
L2315522Certificate of AnalysisDec 01, 2023 L386714
C2415110Certificate of AnalysisDec 01, 2023 L386714
L2315521Certificate of AnalysisDec 01, 2023 L386714
L2315520Certificate of AnalysisDec 01, 2023 L386714
E2326858Certificate of AnalysisMay 17, 2023 L386714
E2326857Certificate of AnalysisMay 17, 2023 L386714
E2326856Certificate of AnalysisMay 17, 2023 L386714
E2326852Certificate of AnalysisMay 17, 2023 L386714
F23081009Certificate of AnalysisSep 27, 2022 L386714
F23081014Certificate of AnalysisSep 27, 2022 L386714
L2202167Certificate of AnalysisSep 27, 2022 L386714
L2202179Certificate of AnalysisSep 27, 2022 L386714
H2223374Certificate of AnalysisJul 30, 2022 L386714
H2223446Certificate of AnalysisJul 30, 2022 L386714
H2223447Certificate of AnalysisJul 30, 2022 L386714

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Chemical and Physical Properties

SolubilitySoluble in water (5 mg/ml).

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Citations of This Product

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References

1. Qiao Chen, Xinmei Duan, Yao Yu, Rongrong Ni, Guojing Song, Xu Yang, Li Zhu, Yuan Zhong, Kun Zhang, Kai Qu, Xian Qin, Wei Wu.  (2023)  Target Functionalized Carbon Dot Nanozymes with Dual-Model Photoacoustic and Fluorescence Imaging for Visual Therapy in Atherosclerosis.  Advanced Science,    (2307441).  [PMID:38145362]
2. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933]
3. Mengyuan Wang, Xingfang Zhang, Juan Guo, Shangze Yang, Fang Yang, Xingjuan Chen.  (2023)  TRPC6 Deletion Enhances eNOS Expression and Reduces LPS—Induced Acute Lung Injury.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (23): (16756).  [PMID:38069081]
4. Qi-Rui Hu, Qing-Xin Huang, Huan Hong, Yao Pan, Ting Luo, Jing Li, Ze-Yuan Deng, Fang Chen.  (2023)  Ginsenoside Rh2 and its octyl ester derivative inhibited invasion and metastasis of hepatocellular carcinoma via the c-Jun/COX2/PGE2 pathway.  PHYTOMEDICINE,  121  (155131).  [PMID:37806155]
5. Qi Guo, Yang Feng, Hongjie Song, Mingxia Sun, Zixuan Zhan, Yi Lv.  (2023)  New Perylene-Based Chemiluminescent Polymer Nanoparticles for Highly Selective Detection of the Superoxide Anion In Vivo.  ANALYTICAL CHEMISTRY,  95  (40): (15102–15109).  [PMID:37779257]
6. Jingyu He, Chen Wang, Gan Lin, Xiao Xia, Hangping Chen, Zhiyuan Feng, Zhengwei Huang, Xin Pan, Xuejuan Zhang, Chuanbin Wu, Ying Huang.  (2023)  Guard against internal and external: An antibacterial, anti-inflammation and healing-promoting spray gel based on lyotropic liquid crystals for the treatment of diabetic wound.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  646  (12): (123442).  [PMID:37774758]
7. Wei Liu, Tengfei Wang, Liwen Wang, Yan Wang, Sheng Hu, Dating Tian.  (2024)  A novel near-infrared fluorescent probe for ultrasensitive and visual detection of mitochondrial viscosity.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  304  (123329).  [PMID:37683438]
8. Hao Zhao, Xin Lin, Qingfeng Chen, Xiaoyue Wang, Yongya Wu, Xiaoxia Zhao.  (2023)  Quercetin inhibits the NOX2/ROS-mediated NF-κB/TXNIP signaling pathway to ameliorate pyroptosis of cardiomyocytes to relieve sepsis-induced cardiomyopathy.  TOXICOLOGY AND APPLIED PHARMACOLOGY,  477  (116672).  [PMID:37648089]
9. Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu.  (2023)  Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway.  BIOMATERIALS,  301  (122259).  [PMID:37531777]
10. Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang, Li Ren.  (2023)  Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect.  FOOD AND CHEMICAL TOXICOLOGY,  179  (113949).  [PMID:37467946]
11. Yajing Wang, Tao Zhang, Jie Liu, Xianfeng Huang, Xiaojing Yan.  (2023)  Investigations of the gingerol oil colon targeting pellets for the treatment of ulcerative colitis.  FITOTERAPIA,  169  (105607).  [PMID:37442485]
12. Jianxin Wang, Peng Guan, Yu Chen, Meng Xu, Na Wang, Ensheng Ji.  (2023)  Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis.  Experimental and Therapeutic Medicine,  26  (2): (1-15).  [PMID:37522059]
13. Mengqi Jia, Ruilin Lu, Caikun Liu, Xiaodong Zhou, Pengfei Li, Shiyong Zhang.  (2023)  In Situ Implantation of Chitosan Oligosaccharide-Doped Lipoic Acid Hydrogel Breaks the “Vicious Cycle” of Inflammation and Residual Tumor Cell for Postoperative Skin Cancer Therapy.  ACS Applied Materials & Interfaces,      [PMID:37358539]
14. Du Jianhao, Zhang Fugui, Chen Min, Xiao Yifei, Zhang Li, Dong Linlin, Dong Dong, Wu Baojian.  (2023)  Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  75  (7): (886-897).  [PMID:37330271]
15. Li Jingyan, Wu Bingmin, Zeng Lishan, Lin Ying, Chen Qiuhe, Wang Haixia, An Lin, Zhang Jiajun, Chen Siyan, Huang Junying, Zhan Ruoting, Zhang Guifang.  (2023)  Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling.  Frontiers in Pharmacology,  14    [PMID:37383718]
16. Qu Xiaoying, Guo Xiaoli, Zhu Tingting, Zhang Zhe, Wang Wanchun, Hao Yuanping.  (2023)  Microneedle patches containing mesoporous polydopamine nanoparticles loaded with triamcinolone acetonide for the treatment of oral mucositis.  Frontiers in Bioengineering and Biotechnology,  11    [PMID:37214298]
17. Yi Liu, Mengyun He, Yi Yuan, Cunpeng Nie, Kaiji Wei, Tong Zhang, Tingting Chen, Xia Chu.  (2023)  Neutrophil-Membrane-Coated Biomineralized Metal–Organic Framework Nanoparticles for Atherosclerosis Treatment by Targeting Gene Silencing.  ACS Nano,  17  (8): (7721–7732).  [PMID:37023215]
18. Yiru Gao, Wenxin Zhang, Rong Xue, Yang Shu, Jianhua Wang.  (2023)  An ionic gel incorporating copper nanodots with antibacterial and antioxidant dual functions for deep tissue penetration treatment of periodontitis in rats.  Biomaterials Science,  11  (10): (3547-3560).  [PMID:37000509]
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