LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
BioReagent, for cell culture, γ-irradiated
Product Description
Lipopolysaccharides (LPS) are intricate molecules consisting of lipids and polysaccharides, predominantly present in the outer membrane of Gram-negative bacteria. Comprising lipid A, the core oligosaccharide (core), and the O-specific polysaccharide or O antigen (OAg), LPS is anchored to the outer bacterial membrane, with lipid A primarily responsible for its associated toxicity. Functioning as a potent activator of the proinflammatory response, LPS engages various mammalian cells, including macrophages, monocytes, and endothelial cells. While serving a protective role for Gram-negative bacteria against environmental stress, LPS also triggers recognition by the innate immune system during infections.
Application:
This LPS serotype has been used to stimulate B-cells and induce NOS in human hepatocytes.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).