Lipopolysaccharides from Salmonella enterica serotype typhimurium

Item Number

L755655

• Specifications & Purity: γ-irradiated, BioReagent, for cell culture
• Biochemical and Physiological Mechanisms: LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: BioReagent, for cell culture, γ-irradiated

Product Description

Lipopolysaccharides from Salmonella enterica serotype typhimurium has been used:

• in mice to elicit the secretion of pro-inflammatory cytokines
• to induce cytokine production in monocytes
• to elicit the activation of NF-κB pathway in mouse dendritic cells.
• to induce inflammatory response in human colon adenocarcinoma Caco-2 cells
• for stimulation of the catfish peripheral blood leukocytes (PBLs) to study estrogen receptor mRNA expression

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).