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Losartan - 97%, high purity , CAS No.114798-26-4, Antagonist of AT 1 receptor

Moligand™
≥97%

CAS#: 114798-26-4
Formula: C₂₂H₂₃ClN₆O
Molecular Weight: 422.92
EC Number: 601-329-8
PubChem CID: 3961

Item Number

L335345

Grouped product items
SKU	Size	Availability	Price
L335345-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$58.90
L335345-5g	5g	In stock	$129.90
L335345-25g	25g	In stock	$585.90
L335345-100g	100g	In stock	$2,106.90

an AT1 inhibitor which prevents the initiation of a signal cascade which causes vasoconstriction

View related series

AT1 receptor Antagonist

Basic Description

Synonyms	losartan\|114798-26-4\|DUP 89\|allisartan\|Angizaar\|Losartic\|Hyzaar\|Cozaar\|Lozap\|LOSARTAN POTASSIUM\|CHEBI:6541\|DUP-89\|DTXSID7023227\|UNII-JMS50MPO89\|JMS50MPO89\|Losartan (INN)\|NSC-758699\|HGP1405\|HGP-1405\|DuP-753\|(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen
Specifications & Purity	97%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of AT 1 receptor
Product Description	Losartan is a potent, non-peptide antagonist of angiotensin II receptor, type 1 (AT1). This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.

Associated Targets

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme 0 Activities

Discover Target: ACE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR2 Tchem Type-2 angiotensin II receptor 0 Activities

Discover Target: AGTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
INCHI	InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
InChi Key	PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Canonical SMILES	CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
Isomeric SMILES	CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
Alternate CAS	114798-26-4,124750-99-8 (mono-potassium salt)
PubChem CID	3961
NSC Number	758699
MeSH Entry Terms	2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;Cozaar;DuP 753;DuP-753;DuP753;Losartan;Losartan Monopotassium Salt;Losartan Potassium;MK 954;MK-954;MK954;Monopotassium Salt, Losartan;Potassium, Losartan;Salt,
Molecular Weight	422.92

PubChem CID

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CAS Registry No.

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RCSB PDB Ligand

Reactome Reaction

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GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
K2216540	Certificate of Analysis	Sep 23, 2022	L335345
K2216541	Certificate of Analysis	Sep 23, 2022	L335345
K2216542	Certificate of Analysis	Sep 23, 2022	L335345

Solubility

Soluble in ethanol (100 mM), and DMSO (100 mM).

Sensitivity

Air sensitive；Heat sensitive

Melt Point(°C)

183.5-184.5° C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H413:May cause long lasting harmful effects to aquatic life H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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