Grouped product items

SKU

Size

Availability

Price

Qty

L129196-10mg

10mg

Available within 4-8 weeks(?)

$48.90

L129196-50mg

50mg

In stock

$187.90

L129196-250mg

250mg

In stock

$846.90

L129196-1g

In stock

$3,045.90

L129196-5g

In stock

$13,705.90

Basic Description

Synonyms	Loteprednol etabonate\|82034-46-6\|Lotemax\|Alrex\|HGP-1\|Inveltys\|CDDD-5604\|P-5604\|CHEBI:31784\|CDDD 5604\|UNII-YEH1EZ96K6\|HGP 1\|YEH1EZ96K6\|EYSUVIS\|DTXSID2046468\|KPI-121\|chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-o
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Loteprednol Etabonate is a "soft" steroid, typically used in topical applications for inflammatory conditions of the eye. Loteprednol Etabonate is an agonist of both glucocorticoid and mineralcorticoid receptors.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Glucocorticoid receptor agonist
Product Description	Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology. An ophthalmic corticosteroid.

Product Properties

ALogP	3.9

Associated Targets

CXCL14 Tbio C-X-C motif chemokine 14 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD1 Tclin D(1A) dopamine receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AVPR1A Tclin Vasopressin V1a receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PGR Tclin Progesterone receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MLNR Tchem Motilin receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
INCHI	InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1
InChi Key	DMKSVUSAATWOCU-HROMYWEYSA-N
Canonical SMILES	CCOC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C(=O)OCCl
Isomeric SMILES	CCOC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C(=O)OCCl
WGK Germany	3
PubChem CID	444025
Molecular Weight	466.95

Database links

DrugBank Ligand	DB00873
PubChem CID	444025
CAS Registry No.	82034-46-6
ChEMBL Ligand	CHEMBL1200865
Wikipedia	Loteprednol
PEP	loteprednol
DrugCentral Ligand	1611

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

9 results found

Lot Number	Certificate Type	Date	Item
K2212236	Certificate of Analysis	Aug 23, 2024	L129196
K2212239	Certificate of Analysis	Aug 23, 2024	L129196
K2212240	Certificate of Analysis	Aug 23, 2024	L129196
K2212215	Certificate of Analysis	Aug 21, 2024	L129196
L2122041	Certificate of Analysis	Oct 23, 2023	L129196
H1510220	Certificate of Analysis	Mar 16, 2023	L129196
I2017210	Certificate of Analysis	Jul 22, 2022	L129196
I2017209	Certificate of Analysis	Jul 22, 2022	L129196
I2017208	Certificate of Analysis	Jul 22, 2022	L129196

Chemical and Physical Properties

Solubility	DMSO 93 mg/mL Water Ethanol 4 mg/mL
Sensitivity	Heat Sensitive
Specific Rotation[α]	40° (C=1,Dioxane)
Melt Point(°C)	226-233°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

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SKU	Size	Availability	Price
L129196-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$48.90
L129196-50mg	50mg	In stock	$187.90
L129196-250mg	250mg	In stock	$846.90
L129196-1g	1g	In stock	$3,045.90
L129196-5g	5g	In stock	$13,705.90

Loteprednol etabonate - ≥98%(HPLC), high purity , Glucocorticoid receptor agonist, CAS No.82034-46-6, Glucocorticoid receptor agonist

Basic Description

Product Properties

Associated Targets

CXCL14 Tbio C-X-C motif chemokine 14 0 Activities

CNR1 Tclin Cannabinoid receptor 1 0 Activities

DRD1 Tclin D(1A) dopamine receptor 0 Activities

DRD2 Tclin D(2) dopamine receptor 0 Activities

ESR1 Tclin Estrogen receptor 0 Activities

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

NR3C1 Tclin Glucocorticoid receptor 0 Activities

AVPR1A Tclin Vasopressin V1a receptor 0 Activities

HRH3 Tclin Histamine H3 receptor 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

HRH1 Tclin Histamine H1 receptor 0 Activities

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

PGR Tclin Progesterone receptor 0 Activities

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

DRD3 Tclin D(3) dopamine receptor 0 Activities

CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

ADORA2A Tclin Adenosine receptor A2a 0 Activities

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

AR Tclin Androgen receptor 0 Activities

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

ADORA1 Tclin Adenosine receptor A1 0 Activities

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

ADORA3 Tchem Adenosine receptor A3 0 Activities

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

EDNRA Tclin Endothelin-1 receptor 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

OPRD1 Tclin Delta-type opioid receptor 0 Activities

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

OPRM1 Tclin Mu-type opioid receptor 0 Activities

MLNR Tchem Motilin receptor 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

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