| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| L658704-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $160.90 |
| Specifications & Purity | ≥98% |
|---|---|
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1 ) inhibitor with IC 50 s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (B Appearance:Solid IC50& Target:IC50: 4.8 nM (Adapter protein-2 associated kinase 1 (AAK1) in enzyme assays); 7.6 nM (AAK1 in cell assays); 24 nM (BMP-2-inducible protein kinase (BIKE)) In Vivo:In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1 ) inhibitor with IC 50 s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase ( |
| Canonical SMILES | O=C(N(C)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C=C3)C(N)=O)OC(C)(C)C.[H]O[H].[1/4] |
|---|---|
| Molecular Weight | 414.98 |
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