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LTURM 34 - ≥98%(HPLC), high purity , CAS No.1879887-96-3

≥98%(HPLC)

CAS#: 1879887-96-3
Formula: C₂₄H₁₈N₂O₃S
Molecular Weight: 414.48
PubChem CID: 122705987

Item Number

L287325

Grouped product items
SKU	Size	Availability	Price
L287325-5mg	5mg	In stock	$78.90
L287325-10mg	10mg	In stock	$137.90
L287325-25mg	25mg	In stock	$296.90
L287325-50mg	50mg	In stock	$513.90
L287325-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$909.90

Potent DNA-PK inhibitor

Basic Description

Synonyms	8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent DNA-PK inhibitor (IC50= 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell linesin vitro.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets

PRKDC Tchem DNA-dependent protein kinase catalytic subunit 0 Activities

Discover Target: PRKDC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0 Activities

Discover Target: PIK3CG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CA Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0 Activities

Discover Target: PIK3CA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CB Tchem Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 Activities

Discover Target: PIK3CB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CD Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 0 Activities

Discover Target: PIK3CD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	8-dibenzothiophen-4-yl-2-morpholin-4-yl-1,3-benzoxazin-4-one
INCHI	InChI=1S/C24H18N2O3S/c27-23-19-9-3-6-16(21(19)29-24(25-23)26-11-13-28-14-12-26)18-8-4-7-17-15-5-1-2-10-20(15)30-22(17)18/h1-10H,11-14H2
InChi Key	SMMSWOMXOZLOPI-UHFFFAOYSA-N
Canonical SMILES	C1COCCN1C2=NC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
Isomeric SMILES	C1COCCN1C2=NC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
PubChem CID	122705987
Molecular Weight	414.48

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2228677	Certificate of Analysis	Sep 22, 2022	L287325
K2228678	Certificate of Analysis	Sep 22, 2022	L287325
K2228683	Certificate of Analysis	Sep 22, 2022	L287325
K2228684	Certificate of Analysis	Sep 22, 2022	L287325
K2228685	Certificate of Analysis	Sep 22, 2022	L287325

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection.

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