LUT014 - 97%, high purity , CAS No.2274819-46-2, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase

Item Number

L412553

Grouped product items
SKU	Size	Availability	Price
L412553-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$39.90
L412553-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,241.90
L412553-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
L412553-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$589.90
L412553-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$939.90

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Basic Description

Synonyms	LUT014\|2274819-46-2\|LUT-014\|N5-(3-(7H-Purin-6-yl)pyridin-2-yl)-6-methyl-N1-(3-(trifluoromethoxy)phenyl)isoquinoline-1,5-diamine\|T4E4I523RY\|6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]-1-N-[3-(trifluoromethoxy)phenyl]isoquinoline-1,5-diamine\|1,5-Isoquinoli
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	LUT014 is an inhibitor of B-Raf with IC50 of 11.7 nM, and reduces dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of B-Raf proto-oncogene; serine/threonine kinase
Product Description	Information LUT014 is an inhibitor of B-Raf with IC50 of 11.7 nM, and reduces dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.

Names and Identifiers

IUPAC Name	6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]-1-N-[3-(trifluoromethoxy)phenyl]isoquinoline-1,5-diamine
INCHI	InChI=1S/C27H19F3N8O/c1-15-7-8-19-18(9-11-32-24(19)37-16-4-2-5-17(12-16)39-27(28,29)30)21(15)38-25-20(6-3-10-31-25)22-23-26(35-13-33-22)36-14-34-23/h2-14H,1H3,(H,31,38)(H,32,37)(H,33,34,35,36)
InChi Key	FZPYULHBUBXPIG-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC(=CC=C3)OC(F)(F)F)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6
Isomeric SMILES	CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC(=CC=C3)OC(F)(F)F)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6
PubChem CID	138319775
Molecular Weight	528.49

PubChem CID

CAS Registry No.

References

1. Li T, Perez-Soler R. (2009) Skin toxicities associated with epidermal growth factor receptor inhibitors.. Target Oncol, 4 (2): (107-19). [PMID:19452131]
2. Lacouture ME, Wainberg ZA, Patel AB, Anadkat MJ, Stemmer SM, Shacham-Shmueli E, Medina E, Zelinger G, Shelach N, Ribas A. (2021) Reducing skin toxicities from EGFR inhibitors with topical BRAF inhibitor therapy.. Cancer Discov, 129 (3): (589-97). [PMID:33910927]

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Basic Description