luvixasertib , CAS No.1610759-22-2, Inhibitor of TTK protein kinase

Item Number

L611619

Grouped product items
SKU	Size	Availability	Price	Qty
L611619-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$240.90
L611619-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$930.90

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Basic Description

Synonyms	CFI-402257\|1610759-22-2\|luvixasertib\|HE97PTK3Q6\|CFI402257\|N-cyclopropyl-4-[7-[(3-hydroxy-3-methylcyclobutyl)methylamino]-5-pyridin-3-yloxypyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzamide\|UNII-HE97PTK3Q6\|CID 118086034\|CHEMBL4442392\|CHEMBL4469414\|CFI 402257
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of TTK protein kinase

Names and Identifiers

IUPAC Name	N-cyclopropyl-4-[7-[(3-hydroxy-3-methylcyclobutyl)methylamino]-5-pyridin-3-yloxypyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzamide
INCHI	InChI=1S/C28H30N6O3/c1-17-10-19(5-8-22(17)27(35)32-20-6-7-20)23-16-31-34-24(30-14-18-12-28(2,36)13-18)11-25(33-26(23)34)37-21-4-3-9-29-15-21/h3-5,8-11,15-16,18,20,30,36H,6-7,12-14H2,1-2H3,(H,32,35)
InChi Key	PMQUGSPFUBGJCZ-UHFFFAOYSA-N
Canonical SMILES	Cc1c(ccc(c1)c1c2nc(cc(n2nc1)NCC1CC(C1)(C)O)Oc1cnccc1)C(=O)NC1CC1
Isomeric SMILES	CC1=C(C=CC(=C1)C2=C3N=C(C=C(N3N=C2)NCC4CC(C4)(C)O)OC5=CN=CC=C5)C(=O)NC6CC6
PubChem CID	118086034

PubChem CID

CAS Registry No.

BindingDB Ligand

References

1. Liu Y, Laufer R, Patel NK, Ng G, Sampson PB, Li SW, Lang Y, Feher M, Brokx R, Beletskaya I et al.. (2016) Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.. ACS Med Chem Lett, 7 (7): (671-5). [PMID:27437075]
2. Mason JM, Wei X, Fletcher GC, Kiarash R, Brokx R, Hodgson R, Beletskaya I, Bray MR, Mak TW. (2017) Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.. Proc Natl Acad Sci U S A, 114 (12): (3127-3132). [PMID:28270606]

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Basic Description