HIF-1α inhibitor (IC 50 values are 2.6 and 0.7 µM for Hep3B and AGS cell lines respectively). Suppresses transcription of HIF-1 target genes VEGF and erythropoietin at 10 µM. Attenuates hypoxia-induced ANP secretion.
Source
Synthetic
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Luo M et al.. (2022) Compression enhances invasive phenotype and matrix degradation of breast Cancer cells via Piezo1 activation.. BMC Mol Cell Biol, 23 (1). [PMID:34979904]
2.Liu H et al.. (2022) miR-138-5p Inhibits Vascular Mimicry by Targeting the HIF-1α/VEGFA Pathway in Hepatocellular Carcinoma.. J Immunol Res, 2022 (7318950). [PMID:35669101]
3.Tang Z et al.. (2022) Taohong Siwu Decoction Promotes Osteo-Angiogenesis in Fractures by Regulating the HIF-1α Signaling Pathway.. Evid Based Complement Alternat Med, 2022 (6777447). [PMID:36193143]
4.Tang Z et al.. (2021) Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1a/VEGF Signaling Pathway.. Evid Based Complement Alternat Med, 2021 (6610116). [PMID:34853600]
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