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LY-2940094 - 98%, high purity , Nociceptin receptor antagonist, CAS No.1307245-86-8, Nociceptin receptor antagonist

Moligand™
≥98%

CAS#: 1307245-86-8
Formula: C₂₂H₂₃ClF₂N₄O₂S
Molecular Weight: 480.96
PubChem CID: 52914971

Item Number

L412379

Grouped product items
SKU	Size	Availability	Price
L412379-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$112.90
L412379-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$539.90
L412379-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$764.90
L412379-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,154.90

View related series

NOP receptor Antagonist

Basic Description

Synonyms	1307245-86-8\|LY2940094\|LY-2940094\|BTRX-246040\|(2-(4-((2'-chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol\|LY 2940094 - Bio-X\|(2-(4-((2-Chloro-4,4-difluoro-spiro(5H-thi
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Nociceptin receptor antagonist
Product Description	Information LY-2940094 is a potent, selective and orally available antagonist of nociceptin receptor (NOP receptor) with Ki of 0.105 nM and Kb of 0.166 nM. LY-2940094 reduces ethanol self-administration in animal models.

Names and Identifiers

IUPAC Name	[2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]pyridin-3-yl]methanol
INCHI	InChI=1S/C22H23ClF2N4O2S/c1-14-16(11-29(27-14)20-15(12-30)3-2-6-26-20)10-28-7-4-21(5-8-28)19-17(9-18(23)32-19)22(24,25)13-31-21/h2-3,6,9,11,30H,4-5,7-8,10,12-13H2,1H3
InChi Key	NKQHBJNRBKHUQR-UHFFFAOYSA-N
Canonical SMILES	CC1=NN(C=C1CN2CCC3(CC2)C4=C(C=C(S4)Cl)C(CO3)(F)F)C5=C(C=CC=N5)CO
Isomeric SMILES	CC1=NN(C=C1CN2CCC3(CC2)C4=C(C=C(S4)Cl)C(CO3)(F)F)C5=C(C=CC=N5)CO
Alternate CAS	1307245-86-8
PubChem CID	52914971
MeSH Entry Terms	2-(4-((2-chloro-4,4-difluorospiro(5H-thieno(2,3-c)pyran-7,4'-piperidine)-1'-yl)methyl)-3-methylpyrazol-1-yl)-3-pyridyl)methanol;LY2940094
Molecular Weight	480.96

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
L2320076	Certificate of Analysis	Nov 24, 2023	L412379
L2320078	Certificate of Analysis	Nov 24, 2023	L412379
L2320081	Certificate of Analysis	Nov 24, 2023	L412379
L2320082	Certificate of Analysis	Nov 24, 2023	L412379
L2320083	Certificate of Analysis	Nov 24, 2023	L412379
L2320084	Certificate of Analysis	Nov 24, 2023	L412379
L2320085	Certificate of Analysis	Nov 24, 2023	L412379

References

1. Toledo MA, Pedregal C, Lafuente C, Diaz N, Martinez-Grau MA, Jiménez A, Benito A, Torrado A, Mateos C, Joshi EM et al.. (2014) Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.. J Med Chem, 57 (8): (3418-29). [PMID:24678969]
2. Witkin JM, Rorick-Kehn LM, Benvenga MJ, Adams BL, Gleason SD, Knitowski KM, Li X, Chaney S, Falcone JF, Smith JW et al.. (2016) Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.. Pharmacol Res Perspect, 4 (6): (e00275). [PMID:28097008]
3. Post A, Smart TS, Krikke-Workel J, Dawson GR, Harmer CJ, Browning M, Jackson K, Kakar R, Mohs R, Statnick M et al.. (2016) A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.. Neuropsychopharmacology, 41 (7): (1803-12). [PMID:26585287]
4. Post A, Smart TS, Jackson K, Mann J, Mohs R, Rorick-Kehn L, Statnick M, Anton R, O'Malley SS, Wong CJ. (2016) Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence.. Alcohol Clin Exp Res, 40 (9): (1935-44). [PMID:27435979]
5. Witkin JM, Wallace TL, Martin WJ. (2019) Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094).. Handb Exp Pharmacol, 254 (3): (399-415). [PMID:30701317]
6. Ferrari F, Rizzo S, Ruzza C, Calo G. (2020) Detailed In Vitro Pharmacological Characterization of the Clinically Viable Nociceptin/Orphanin FQ Peptide Receptor Antagonist BTRX-246040.. J Pharmacol Exp Ther, 373 (1): (34-43). [PMID:31937563]

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LY-2940094 - 98%, high purity , Nociceptin receptor antagonist, CAS No.1307245-86-8, Nociceptin receptor antagonist

Basic Description

Product Properties

Associated Targets

OPRL1 Tchem Nociceptin receptor 1 Activities