| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| L274839-1mg | 1mg | In stock | $93.90 | |
| L274839-5mg | 5mg | In stock | $201.90 |
Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor
| Synonyms | LY333531 HCl | (9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride;LY333531 Hydrochloride | 9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[ |
|---|---|
| Specifications & Purity | ≥97% |
| Biochemical and Physiological Mechanisms | Potent, isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Competitively inhibits\xa0PKCßI and PKCßII (IC 50 values are 4.7 and 5.9 nM respectively). 76- and 61-fold selective for inhibition of PKCßI and PKCßII in comparison to PKCα, respectively. |
| Storage Temp | Protected from light,Store at -20°C,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Shipped at 4°C. Store at -20°C. Store under desiccating conditions. |
| Pubchem Sid | 488196381 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488196381 |
| IUPAC Name | (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione;hydrochloride |
| INCHI | InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1 |
| InChi Key | NYQIEYDJYFVLPO-FERBBOLQSA-N |
| Canonical SMILES | CN(C)CC1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl |
| Isomeric SMILES | CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl |
| WGK Germany | 3 |
| PubChem CID | 9870785 |
| Molecular Weight | 505.01 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2331621 | Certificate of Analysis | Jan 15, 2024 | L274839 |
| C2331556 | Certificate of Analysis | Jan 15, 2024 | L274839 |
| C2331561 | Certificate of Analysis | Jan 11, 2024 | L274839 |
| C2331613 | Certificate of Analysis | Jan 11, 2024 | L274839 |
| Solubility | Soluble in DMSO to 20 mM |
|---|---|
| Sensitivity | Light sensitive;Moisture sensitive |
| WGK Germany | 3 |
|---|---|
| RIDADR | NONHforallmodesoftransport |
Starting at $241.90
| 1. Zhang H et al.. (2022) Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala.. J Neurochem, 161 (6): (478-491). [PMID:35583089] |
