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LY 367385 - ≥99%, high purity , CAS No.198419-91-9, Antagonist of mGlu 1 receptor

  • Moligand™
  • ≥99%
Item Number
L274915
Grouped product items
SKUSizeAvailabilityPrice Qty
L274915-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$181.90
L274915-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$761.90

mGlu 1a antagonist

View related series
mGlu1 receptor Antagonist

Basic Description

Synonyms198419-91-9|LY367385|LY 367385|LY-367385|UNII-D8UW47H17B|D8UW47H17B|2-methyl-4-carboxyphenylglycine|4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid|CHEMBL94631|4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]-3-methylbenzoic acid|Benzeneacetic acid, alpha-amino-4-
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsPotent, selective mGlu 1a antagonist. Neuroprotective and anticonvulsant in vivo .
Storage TempRoom temperature,Desiccated
Shipped InNormal
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of mGlu 1 receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM1 Tchem Metabotropic glutamate receptor 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid
INCHI InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
InChi Key SGIKDIUCJAUSRD-QMMMGPOBSA-N
Canonical SMILES CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N
Isomeric SMILES CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
PubChem CID 5311261
Molecular Weight 209.2

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in 1.1 eq. NaOH to 100 mM

Related Documents

References

1. Min R & Nevian T.  (2012)  Astrocyte signaling controls spike timing-dependent depression at neocortical synapses..  Nat Neurosci,  15  (5): (746-53).  [PMID:22446881]
2. Robin LM et al..  (2018)  Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory..  Neuron,  98  (5): (935-944.e5).  [PMID:29779943]
3. Younts TJ et al..  (2013)  CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses..  J Neurosci,  33  (34): (13743-57).  [PMID:23966696]
4. Bragina L et al..  (2015)  Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals..  Front Cell Neurosci,  (345).  [PMID:26388733]
5. Fenselau H et al..  (2011)  Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons..  J Neurosci,  31  (48): (17383-91).  [PMID:22131400]
6. Colavita M et al..  (2016)  Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus..  Sci Rep,  (28454).  [PMID:27345695]
7. Li DP & Pan HL.  (2010)  Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension..  Am J Physiol Regul Integr Comp Physiol,  299  (2): (R552-61).  [PMID:20519363]
8. Robberechts Q et al..  (2010)  Long-term depression at parallel fiber to Golgi cell synapses..  J Neurophysiol,  104  (6): (3413-23).  [PMID:20861429]
9. Cosgrove KE & Maccaferri G.  (2012)  mGlu1a-dependent recruitment of excitatory GABAergic input to neocortical Cajal-Retzius cells..  Neuropharmacology,  63  (3): (486-93).  [PMID:22579657]
10. Crandall SR & Cox CL.  (2013)  Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus..  J Neurophysiol,  110  (2): (470-80).  [PMID:23615551]
11. Eng AG et al..  (2016)  Transduction of group I mGluR-mediated synaptic plasticity by ß-arrestin2 signalling..  Nat Commun,  (13571).  [PMID:27886171]

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