Potent, selective mGlu 1a antagonist. Neuroprotective and anticonvulsant in vivo .
Storage Temp
Room temperature,Desiccated
Shipped In
Normal
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of mGlu 1 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Min R & Nevian T. (2012) Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.. Nat Neurosci, 15 (5):(746-53). [PMID:22446881]
2.Robin LM et al.. (2018) Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory.. Neuron, 98 (5):(935-944.e5). [PMID:29779943]
3.Younts TJ et al.. (2013) CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.. J Neurosci, 33 (34):(13743-57). [PMID:23966696]
4.Bragina L et al.. (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.. Front Cell Neurosci, 9 (345). [PMID:26388733]
5.Fenselau H et al.. (2011) Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons.. J Neurosci, 31 (48):(17383-91). [PMID:22131400]
6.Colavita M et al.. (2016) Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.. Sci Rep, 6 (28454). [PMID:27345695]
7.Li DP & Pan HL. (2010) Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension.. Am J Physiol Regul Integr Comp Physiol, 299 (2):(R552-61). [PMID:20519363]
8.Robberechts Q et al.. (2010) Long-term depression at parallel fiber to Golgi cell synapses.. J Neurophysiol, 104 (6):(3413-23). [PMID:20861429]
9.Cosgrove KE & Maccaferri G. (2012) mGlu1a-dependent recruitment of excitatory GABAergic input to neocortical Cajal-Retzius cells.. Neuropharmacology, 63 (3):(486-93). [PMID:22579657]
10.Crandall SR & Cox CL. (2013) Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus.. J Neurophysiol, 110 (2):(470-80). [PMID:23615551]
11.Eng AG et al.. (2016) Transduction of group I mGluR-mediated synaptic plasticity by ß-arrestin2 signalling.. Nat Commun, 7 (13571). [PMID:27886171]
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