Highly potent and systemically active mGlu 2 and mGlu 3 agonist. EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 , respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke,
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of mGlu 2 receptor;Agonist of mGlu 3 receptor;Agonist of mGlu 6 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM. (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.. J Neurosci, 34 (1):(79-94). [PMID:24381270]
2.Liu J et al.. (2021) Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.. Neural Regen Res, 16 (4):(727-733). [PMID:33063735]
3.Bragina L et al.. (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.. Front Cell Neurosci, 9 (345). [PMID:26388733]
4.Klakotskaia D et al.. (2013) Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning.. Behav Brain Res, 253 (9-16). [PMID:23827202]
5.Špirková A et al.. (2022) Glutamate can act as a signaling molecule in mouse preimplantation embryos†.. Biol Reprod, 107 (4):(916-927). [PMID:35746896]
6.Gosnell HB et al.. (2011) mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.. Neuropsychopharmacology, 36 (8):(1599-607). [PMID:21451497]
7.Rylander D et al.. (2009) Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.. J Pharmacol Exp Ther, 330 (227-35). [PMID:19357321]
8.Cuccurazzu B et al.. (2013) Upregulation of mGlu2 Receptors via NF-?B p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine.. Neuropsychopharmacology, 38 (11):(2220-30). [PMID:23670591]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
A2422002